| Identification | Back Directory | [Name]
2,5-Pyrrolidinedione, 3-amino-, (3S)- | [CAS]
73537-92-5 | [Synonyms]
(S)-Aspartimide
(S)-3-Aminopyrrolidine-2,5-dione
2,5-Pyrrolidinedione, 3-amino-, (3S)- | [Molecular Formula]
C4H6N2O2 | [MDL Number]
MFCD11894500 | [MOL File]
73537-92-5.mol | [Molecular Weight]
114.1 |
| Chemical Properties | Back Directory | [Boiling point ]
337.0±35.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [solubility ]
DMSO: soluble; Methanol: soluble | [form ]
A solid | [pka]
8.93±0.50(Predicted) |
| Hazard Information | Back Directory | [Description]
(S)-Aspartimide is a byproduct formed during solid-phase peptide synthesis (SPPS) of aspartic acid-containing peptides.1 Aspartimide is formed by cyclization of aspartic acid during Fmoc removal or peptide coupling.2 | [Uses]
(S)-3-Aminopyrrolidine-2,5-dione is a potential anticonvulsant agent and its derivatives have comparable in vivo potency[1]. | [References]
1. Ruczyński, J., Lewandowska, B., Mucha, P., et al. Problem of aspartimide formation in Fmoc-based solid-phase peptide synthesis using Dmab group to protect side chain of aspartic acid J. Pept. Sci. 14(3),335-341(2008).
2. Neumann, K., Farnung, J., Baldauf, S., et al. Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups Nat. Commun. 11(1),982(2020). |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|