| Identification | Back Directory | [Name]
2,5-Pyrrolidinedione, 3-amino-, (3R)- | [CAS]
404887-22-5 | [Synonyms]
(R)-Aspartimide
(R)-3-Aminopyrrolidine-2,5-dione
2,5-Pyrrolidinedione, 3-amino-, (3R)- | [Molecular Formula]
C4H6N2O2 | [MDL Number]
MFCD19207316 | [MOL File]
404887-22-5.mol | [Molecular Weight]
114.1 |
| Hazard Information | Back Directory | [Description]
(R)-Aspartimide is a byproduct formed during solid-phase peptide synthesis (SPPS) of aspartic acid-containing peptides.1 Aspartimide is formed by cyclization of aspartic acid during Fmoc removal or peptide coupling.2 | [Uses]
(R)-3-Aminopyrrolidine-2,5-dione is a potential anticonvulsant agent and its derivatives have comparable in vivo efficacy[1]. | [References]
1. Ruczyński, J., Lewandowska, B., Mucha, P., et al. Problem of aspartimide formation in Fmoc-based solid-phase peptide synthesis using Dmab group to protect side chain of aspartic acid J. Pept. Sci. 14(3),335-341(2008).
2. Neumann, K., Farnung, J., Baldauf, S., et al. Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups Nat. Commun. 11(1),982(2020). |
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