| Identification | Back Directory | [Name]
CORTISOL-9,11,12,12-D4 | [CAS]
73565-87-4 | [Synonyms]
Hycort-d4
Hycortol-d4
Texacort-d4
TiMocort-d4
Cortisol-d4
Acticort-d4
DerMacort-d4
[2H4]-Cortisol
Hydrocortal-d4
Deuterated cortisol
CORTISOL-9,11,12,12-D4
11β-Hydroxycortisone-d4
Cortisol-[d4] (Solution)
Deuterated hydrocortisone
Pregn-4-ene-3,20-dione-d4
17-Hydroxycorticosterone-d4
Cortisol-D4 (9,11,12,12-D4)
HYDROCORTISONE (9,11,12,12-D4)
Cortisol-[D4] (CertiMass solution)
Cortisol-D4 (9,11,12,12-D4) solution
Hydrocortisone-9,11,12,12-D4 solution
Cortisol-D4 (9,11,12, 12-D4) solution
4-Pregnene-11β,17α,21-triol-3,20-dione-D4
11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-D4
(11β)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione-d4
Pregn-4-ene-3,20-dione-9,11,12,12-d4,11,17,21-trihydroxy-, (11b)-
(8S,10R,11S,13S)-9,11,12,12-tetradeuterio-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Hydrocortisone D4Q: What is
Hydrocortisone D4 Q: What is the CAS Number of
Hydrocortisone D4 Q: What is the storage condition of
Hydrocortisone D4 Q: What are the applications of
Hydrocortisone D4
17-Hydroxycorticosterone-9,11,12,12-d4, Cortisol-9,11,12,12-d4, Hydrocortisone-9,11,12,12-d4, Kendall's compound F (9,11,12,12-d4), Reichstein's substance M (9,11,12,12-d4), 4-Pregnene-11β,17α,21-triol-3,20-dione-d4 (9,11,12,12-d4), 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-d4 (9,11,12,12-d4) | [EINECS(EC#)]
694-327-1 | [Molecular Formula]
C21H26D4O4 | [MDL Number]
MFCD00144010 | [MOL File]
73565-87-4.mol | [Molecular Weight]
350.49 |
| Chemical Properties | Back Directory | [Melting point ]
211-214 °C | [Fp ]
9℃ | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly, Heated), Water | [form ]
Solid | [color ]
White to Off-White | [Appearance]
white powder | [Major Application]
clinical testing
clinical testing | [InChIKey]
JYGXADMDTFJGBT-BJJKTIQHSA-N | [SMILES]
[2H]C1([2H])[C@]([2H])(O)[C@@]2([2H])[C@@H](CCC3=CC(=O)CC[C@]23C)[C@@H]4CCC(O)(C(=O)CO)[C@@]14C | [CAS Number Unlabeled]
50-23-7 |
| Hazard Information | Back Directory | [Description]
Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson''s disease. | [Chemical Properties]
White Solid | [Uses]
Anti-inflammatory hormone | [Uses]
Labelled Cortisol (H714615). Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism. | [General Description]
Cortisol, also known as hydrocortisone, is a glucocorticoid produced by the adrenal gland. This stable labeled internal standard is suitable for quantitation of cortisol levels in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing′s syndrome, Addison′s disease, and Sheehan′s syndrome. | [References]
[1] KRIEGER D T. Rhythms of acth and corticosteroid secretion in health and disease, and their experimental modification[J]. Journal of steroid biochemistry, 1975, 6 5: Pages 785-791. DOI: 10.1016/0022-4731(75)90068-0
[2] BOADIE W. DUNLOP Andrea W. The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2019, 89: Pages 361-379. DOI: 10.1016/j.pnpbp.2018.10.010
[3] PAUL M. STEWART Christopher R W E. The cortisol-cortisone shuttle and hypertension[J]. Journal of Steroid Biochemistry and Molecular Biology, 1991, 40 4: Pages 501-509. DOI: 10.1016/0960-0760(91)90269-b
[4] FEMINA P. VARGHESE E S B. The Hypothalamic-Pituitary-Adrenal Axis in Major Depressive Disorder: A Brief Primer for Primary Care Physicians.[J]. Primary care companion to the Journal of clinical psychiatry, 2001, 3 4: 151-155. DOI: 10.4088/pcc.v03n0401
[5] NAYRON MEDEIROS SOARES. Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson’s disease: a systematic review.[J]. Journal of Neural Transmission, 2019, 126 3: 219-232. DOI: 10.1007/s00702-018-1947-4 |
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