| Identification | More | [Name]
CORTEXOLONE | [CAS]
152-58-9 | [Synonyms]
11-DEOXY-17-HYDROXYCORTICOSTERONE
11-DEOXYCORTISOL
11-DESOXY-17-HYDROXYCORTICOSTERONE
11-DESOXYCORTISOL
17,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
17,21-DIHYDROXYPROGESTERONE
17ALPHA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
17ALPHA,21-DIHYDROXYPREGNA-4-ENE-3,20-DIONE
17ALPHA-HYDROXYCORTEXONE
4-PREGNEN-17,21-DIOL-3,20-DIONE
4-PREGNEN-17A 21-DIOL-3,20-DIONE
4-PREGNEN-17ALPHA,21-DIOL-3,20-DIONE
4-PREGNENE-17ALPHA,21-DIOL-3,20-DIONE
(8R,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
CORTEXOLONE
CORTODOXONE
REICHSTEIN'S COMPOUND ''S''
REICHSTEIN'S SUBSTANCE S
REICHSTEIN'S SUBSTANCE ''S''
REICHSTEIN'S SUBSTANCE 'S' | [EINECS(EC#)]
205-805-2 | [Molecular Formula]
C21H30O4 | [MDL Number]
MFCD00003662 | [Molecular Weight]
346.46 | [MOL File]
152-58-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
205-208 °C
| [Boiling point ]
401.19°C (rough estimate) | [density ]
1.22±0.1 g/cm3 (20 ºC 760 Torr) | [refractive index ]
120 ° (C=1, Dioxane) | [Fp ]
9℃ | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Dioxane (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
12?+-.0.60(Predicted) | [color ]
White to Off-White | [Water Solubility ]
44.08mg/L(37 ºC) | [Usage]
Glucocorticoid receptor binding | [Merck ]
2932 | [InChI]
InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1 | [InChIKey]
WHBHBVVOGNECLV-OBQKJFGGSA-N | [SMILES]
C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](O)(C(=O)CO)CC3)CC2 | [CAS DataBase Reference]
152-58-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS02,GHS06,GHS08 | [Signal word ]
Danger | [Hazard statements ]
H225-H301+H311+H331-H370 | [Precautionary statements ]
P210-P260-P280-P301+P310-P311 | [Hazard Codes ]
F,T | [Risk Statements ]
11-23/24/25-39/23/24/25 | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [RIDADR ]
UN1230 - class 3 - PG 2 - Methanol, solution | [WGK Germany ]
3 | [RTECS ]
TU5011500 | [HS Code ]
2937.23.5050 | [Toxicity]
mouse,LD50,intravenous,100mg/kg (100mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04684, |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
11-Deoxy Cortisol (Hydrocortisone EP Impurity F) is a glucocorticoid receptor binding. | [Uses]
Glucocorticoid receptor binding | [Definition]
ChEBI:11-deoxycortisol is a deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen. It has a role as a mouse metabolite and a human metabolite. It is a glucocorticoid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone and a deoxycortisol. | [in vivo]
Cortodoxone (100 mg/kg; i.p.) increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone[1]. | Animal Model: | 220-320g, adult male Wistar rats[2] | | Dosage: | 100 mg/kg | | Administration: | IP | | Result: | Increased tryptophan oxygenase (TO) activity and induced the secretion of corticosterone. |
| [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|