| Identification | Back Directory | [Name]
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH | [CAS]
73634-68-1 | [Synonyms]
PYR-LYENKPRRPWIL
[D-TRP11]-NEUROTENSIN
GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-DTRP-ILE-LEU
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH
pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH | [Molecular Formula]
C80H122N22O19 | [MDL Number]
MFCD00076683 | [MOL File]
73634-68-1.mol | [Molecular Weight]
1695.96 |
| Hazard Information | Back Directory | [Uses]
[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension[1][2]. | [in vivo]
[D-Trp11]-Neurotensin (50-500 nmol/kg; i.v.) has hypotensive activity in pentobarbital-anesthetized rats, with an ED25 of 122 nmol/kg[2]. | [References]
[1] Quirion R, et, al. Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue. Eur J Pharmacol. 1980 Feb 8;61(3):309-12. DOI:10.1016/0014-2999(80)90133-8
[2] Quirion R, et, al. Hypotensive effects of centrally and peripherally administered neurotensin and neurotensin derivatives in rats. Neuropeptides. 1981 Jou. 1(4): 253-9. |
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