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73819-26-8

73819-26-8 Structure

73819-26-8 Structure
IdentificationBack Directory
[Name]

4,4'-(2,5-Furandiyl)bis(benzenecarboximidamide)
[CAS]

73819-26-8
[Synonyms]

NSC 305831
FuraMidine-d8
NSC 305831-d8
2,5-Bis(4-guanylphenyl)furan
2,5-bis(4-amidinophenyl)furan
2,5-Bis(4-guanylphenyl)furan-d8
2,5-Bis(4-aMidinophenyl)furan-d8
4,4'-(2,5-Furandiyl)bis(benzenecarboximidamide)
Benzenecarboximidamide, 4,4'-(2,5-furandiyl)bis-
4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzenecarboximidamide
[Molecular Formula]

C18H16N4O
[MDL Number]

MFCD01656960
[MOL File]

73819-26-8.mol
[Molecular Weight]

304.35
Hazard InformationBack Directory
[Uses]

Labelled analogue of Furamidine, a diphenylfuran compound belonging to an important class of antimicrobial and antiparasitic agents. Furamidine and its analogues also display antitumor activities and showed antiproliferative activities against various tumor cell lines.
[in vivo]

Furamidine (1 mg/kg; intraperitoneal injection; 3 times a week and repeated every 4 weeks; for 34 weeks; female NZB/NZW mice) and Irinotecan combined treatment suppresses proteinuria and prolongs survival of lupus-prone NZB/NZW mice. The combination treatment does not change the levels of anti-dsDNA antibodies[3].

Animal Model:Female NZB/NZW mice (6-week-old) with Irinotecan (1 mg/kg)[3]
Dosage:1 mg/kg
Administration:Intraperitoneal injection; 3 times a week and repeated every 4 weeks; for 34 weeks
Result:Suppressed proteinuria and prolongs survival of lupus-prone NZB/NZW mice combined with Irinotecan.
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