| Identification | Back Directory | [Name]
1-Hydroxymethyl-1,2,4-triazole | [CAS]
74205-82-6 | [Synonyms]
1,2,4-Triazole-1-methanol
1H-1,2,4-Triazole-1-methanol
1-Hydroxymethyl-1,2,4-triazole
(1H-1,2,4-Triazol-1-yl)Methanol | [Molecular Formula]
C3H5N3O | [MDL Number]
MFCD00227137 | [MOL File]
74205-82-6.mol | [Molecular Weight]
99.09 |
| Chemical Properties | Back Directory | [Melting point ]
70-71℃ | [Boiling point ]
290℃ | [density ]
1.42 | [Fp ]
129℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
11.58±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Uses]
1-Hydroxymethyl-1,2,4-triazole is useful in the synthesis of novel triazole compounds that have anti-fungal properties. | [Synthesis]
Step 1. Preparation of (1H-1,2,4-triazol-1-yl)methanol
1H-1,2,4-triazole (7.04 g, 102 mmol) was mixed with paraformaldehyde (3.06 g, 102 mmol) and catalytic amount of triethylamine was added. The mixture was heated to a molten state (140°C) and stirred at this temperature for 0.5 hours. After completion of the reaction, the reaction mixture was cooled to 30 °C to give a white solid product (9.0 g, 89% yield). | [References]
[1] Heterocyclic Communications, 2001, vol. 7, # 6, p. 577 - 582
[2] Phosphorus and Sulfur and the Related Elements, 1987, vol. 33, p. 41 - 52
[3] Tetrahedron, 2010, vol. 66, # 47, p. 9145 - 9150
[4] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980, vol. 16, # 2, p. 189 - 194
[5] Khimiya Geterotsiklicheskikh Soedinenii, 1980, vol. 16, # 2, p. 251 - 256 |
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Energy Chemical
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www.energy-chemical.com |
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Cool Pharm, Ltd
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