| Identification | Back Directory | [Name]
2-BENZYLOXY-5-BROMO-PYRIMIDINE | [CAS]
742058-39-5 | [Synonyms]
2-BENZYLOXY-5-BROMO-PYRIMIDINE
5-bromo-2-phenylmethoxypyrimidine
Pyrimidine, 5-bromo-2-(phenylmethoxy)-
2-BENZYLOXY-5-BROMO-PYRIMIDINE ISO 9001：2015 REACH | [Molecular Formula]
C11H9BrN2O | [MDL Number]
MFCD07375140 | [MOL File]
742058-39-5.mol | [Molecular Weight]
265.11 |
| Chemical Properties | Back Directory | [Melting point ]
100-103°C | [Boiling point ]
392.6±44.0 °C(Predicted) | [density ]
1.499±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
-0.21±0.22(Predicted) | [Appearance]
Light yellow to yellow Solid | [CAS DataBase Reference]
742058-39-5 |
| Hazard Information | Back Directory | [Uses]
2-(Benzyloxy)-5-bromopyrimidine is a pharmaceutical intermediate compound that can be used in the preparation of protein tyrosine phosphatase 2 (SHP2) inhibitors. | [Synthesis]
Synthesis of 2-(Benzyloxy)-5-bromopyrimidine:
At room temperature, 5-bromo-2-chloropyrimidine (3.00 g, 15.51 mmol), benzyl alcohol (1.84 g, 17.06 mmol) and DMF (10 mL) were sequentially added to the flask. Potassium tert-butylate (2.82 g, 23.26 mmol) was added in portions. The mixture reacted at room temperature for 2 hours. Water was added, and the mixture was filtered to yield 2.10 g of the pure product, a yield of 51%. |
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