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745053-64-9

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745053-64-9 Structure

745053-64-9 Structure

Identification	Back Directory
[Name] 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE
[CAS] 745053-64-9
[Synonyms] 2-Amine-5-Fluorothiazol HCL 5-Fluorothiazol-2-aMine HCl 2-AMino-5-fluorothiazole HCl 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE 5-Fluorothiazole-2-aMine hydrochloride 5-Fluroro-2-thiazolaMine hydrochloride 2-ThiazolaMine,5-fluoro-, hydrochloride 5-Fluoro-thiazol-2-ylamine hydrochloride 2-Amino-5-fluorothiazole hydrochloride 95% 5-Fluoro-1,3-thiazol-2-amine hydrochloride 2-Amino-5-fluoro-1,3-thiazole hydrochloride 5-fluorothiazol-2-amine,hydrochloride (1:1) 2-ThiazolaMine, 5-fluoro-, Monohydrochloride 2-Thiazolamine, 5-fluoro-, hydrochloride (1:1) 2-Amino-5-fluoro-1,3-thiazole hydrochloride 97% 5-fluoro-1,3-thiazol-2-amine hydrochloride (1:1)
[Molecular Formula] C3H3FN2S.HCl
[MDL Number] MFCD09056854
[MOL File] 745053-64-9.mol
[Molecular Weight] 154.59

Chemical Properties	Back Directory
[Melting point ] 138-143°C
[storage temp. ] under inert gas (nitrogen or Argon) at 2-8°C
[form ] solid
[Appearance] Yellow to brown Solid
[CAS DataBase Reference] 745053-64-9

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302+H312+H332-H315-H319-H335
[Precautionary statements ] P261-P271-P280
[WGK Germany ] 3
[HS Code ] 2934100090

Hazard Information	Back Directory
[Uses] 5-Fluorothiazol-2-amine Hydrochloride can be used as anti-tumor agents.
[Synthesis] 731018-54-5 745053-64-9 b) Synthesis of 5-fluorothiazol-2-amine hydrochloride; N-(5-fluoro-2-thiazolyl)-carbamic acid-1,1-dimethylethyl ester (4.6 g, 21.1 mmol) was dissolved in dioxane (25 mL). HCl gas was passed into the solution for 4 h. Subsequently, ether (50 mL) was added to form a suspension and the solid was collected by filtration. The resulting solid was dried under high vacuum to give 5-fluorothiazol-2-amine hydrochloride (3.03 g, 19.7 mmol, 93% yield). The product was confirmed by 1H NMR (D2O): δ 7.00 (1H, d); mass spectrometry analysis showed m/z = 119.0 [M + H]+.
[References] [1] Organic Process Research and Development, 2006, vol. 10, # 2, p. 346 - 348 [2] Patent: WO2006/16178, 2006, A1. Location in patent: Page/Page column 9 [3] Patent: WO2006/16174, 2006, A1. Location in patent: Page/Page column 17 [4] Patent: EP2105435, 2009, A1. Location in patent: Page/Page column 54-55 [5] Patent: WO2012/51450, 2012, A1. Location in patent: Page/Page column 28

Spectrum Detail	Back Directory
[Spectrum Detail] 5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE(745053-64-9)¹HNMR

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