| Identification | Back Directory | [Name]
5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE | [CAS]
745053-64-9 | [Synonyms]
2-Amine-5-Fluorothiazol HCL
5-Fluorothiazol-2-aMine HCl
2-AMino-5-fluorothiazole HCl
5-FLUOROTHIAZOL-2-AMINE HYDROCHLORIDE
5-Fluorothiazole-2-aMine hydrochloride
5-Fluroro-2-thiazolaMine hydrochloride
2-ThiazolaMine,5-fluoro-, hydrochloride
5-Fluoro-thiazol-2-ylamine hydrochloride
2-Amino-5-fluorothiazole hydrochloride 95%
5-Fluoro-1,3-thiazol-2-amine hydrochloride
2-Amino-5-fluoro-1,3-thiazole hydrochloride
5-fluorothiazol-2-amine,hydrochloride (1:1)
2-ThiazolaMine, 5-fluoro-, Monohydrochloride
2-Thiazolamine, 5-fluoro-, hydrochloride (1:1)
2-Amino-5-fluoro-1,3-thiazole hydrochloride 97%
5-fluoro-1,3-thiazol-2-amine hydrochloride (1:1) | [Molecular Formula]
C3H3FN2S.HCl | [MDL Number]
MFCD09056854 | [MOL File]
745053-64-9.mol | [Molecular Weight]
154.59 |
| Hazard Information | Back Directory | [Uses]
5-Fluorothiazol-2-amine Hydrochloride can be used as anti-tumor agents. | [Synthesis]
b) Synthesis of 5-fluorothiazol-2-amine hydrochloride; N-(5-fluoro-2-thiazolyl)-carbamic acid-1,1-dimethylethyl ester (4.6 g, 21.1 mmol) was dissolved in dioxane (25 mL). HCl gas was passed into the solution for 4 h. Subsequently, ether (50 mL) was added to form a suspension and the solid was collected by filtration. The resulting solid was dried under high vacuum to give 5-fluorothiazol-2-amine hydrochloride (3.03 g, 19.7 mmol, 93% yield). The product was confirmed by 1H NMR (D2O): δ 7.00 (1H, d); mass spectrometry analysis showed m/z = 119.0 [M + H]+. | [References]
[1] Organic Process Research and Development, 2006, vol. 10, # 2, p. 346 - 348
[2] Patent: WO2006/16178, 2006, A1. Location in patent: Page/Page column 9
[3] Patent: WO2006/16174, 2006, A1. Location in patent: Page/Page column 17
[4] Patent: EP2105435, 2009, A1. Location in patent: Page/Page column 54-55
[5] Patent: WO2012/51450, 2012, A1. Location in patent: Page/Page column 28 |
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