Identification | More | [Name]
3-IODO-4-METHOXYANILINE | [CAS]
74587-12-5 | [Synonyms]
3-Iodo-p-anisidine 4-Amino-2-iodoanisole 3-IODO-4-METHOXYANILINE 3-Iodo-4-methoxyaniline> 3-Iodo-4-methoxyaniline,98% 3-Iodo-4-methoxybenzenamine 3-Iodo-4-methoxy-phenylamine BenzenaMine,3-iodo-4-Methoxy- 4-Amino-2-iodoanisole, 3-Iodo-p-anisidine (3-iodo-4-methoxyphenyl)amine hydrochloride 4-AMino-2-iodoanisole[3-Iodo-4-Methoxyaniline] | [Molecular Formula]
C7H8INO | [MDL Number]
MFCD06656566 | [Molecular Weight]
249.05 | [MOL File]
74587-12-5.mol |
Chemical Properties | Back Directory | [Melting point ]
74 °C | [Boiling point ]
321℃ | [density ]
1.807 | [Fp ]
148℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
4.24±0.10(Predicted) | [color ]
White to Gray to Brown | [InChIKey]
UHPNLGCUIGEZRB-UHFFFAOYSA-N | [CAS DataBase Reference]
74587-12-5(CAS DataBase Reference) |
Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-iodo-4-methoxyaniline from 2-iodo-4-nitroanisole: To a 250 mL round-bottomed flask were added 2-iodo-1-methoxy-4-nitrobenzene (6 g, 21.50 mmol, 1.00 eq.), iron powder (3.61 g, 64.50 mmol, 3.00 eq.), ammonium chloride (3.42 g, 63.94 mmol , 3.00 equiv), ethanol (50 mL) and water (10 mL). The reaction mixture was stirred at 85 °C for 1 hour. Upon completion of the reaction, the solid insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure. The brown solid product 3-iodo-4-methoxyaniline (5.35 g, 100% yield) was obtained. The product was analyzed by liquid chromatography-mass spectrometry (LC-MS): (electrospray ionization, m/z) retention time (RT) = 0.847 min, LCMS 53: m/z = 250 [M + 1]. | [References]
[1] Patent: WO2018/118842, 2018, A1. Location in patent: Paragraph 0421-0424 [2] Patent: WO2016/199943, 2016, A1. Location in patent: Paragraph 0303 [3] Patent: WO2013/14039, 2013, A1. Location in patent: Page/Page column 45-46 [4] Patent: WO2014/152029, 2014, A2. Location in patent: Paragraph 00230 [5] Journal of the American Chemical Society, 1941, vol. 63, p. 2482,2484 |
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