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74654-05-0

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74654-05-0 Structure

74654-05-0 Structure
IdentificationBack Directory
[Name]

Methyl-PEG3-MS
[CAS]

74654-05-0
[Synonyms]

mPEG3-MS
m-PEG4-Ms
m-PEG3-OMs
CAS_74654-05-0
Methyl-PEG3-MS
mPEG3-Methanesulfonate
2-(2-[2-Methoxyethoxy]ethoxy)ethyl methanesulfonate
Ethanol, 2-[2-(2-methoxyethoxy)ethoxy]-, methanesulfonate
Ethanol, 2-[2-(2-methoxyethoxy)ethoxy]-, 1-methanesulfonate
[Molecular Formula]

C8H18O6S
[MDL Number]

MFCD00956358
[MOL File]

74654-05-0.mol
[Molecular Weight]

242.29
Chemical PropertiesBack Directory
[Boiling point ]

152 °C(Press: 0.01 Torr)
[density ]

1.170±0.06 g/cm3(Predicted)
[form ]

Liquid
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]

GHS hazard pictograms
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501
Hazard InformationBack Directory
[Description]

m-PEG4-Ms is a PEG linker containing a mesyl group. The mesyl group is a good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
[Uses]

m-PEG3-OMs is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Spectrum DetailBack Directory
[Spectrum Detail]

Methyl-PEG3-MS(74654-05-0)1HNMR
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