| Identification | Back Directory | [Name]
Cholesteryl Eicosapentaenoate | [CAS]
74892-97-0 | [Synonyms]
CE(20:5(5Z,8Z,11Z,14Z,17Z)
CHOLESTERYL EICOSAPENTAENOATE
Cholesteryl eicosapentaenoic acid
cholesteryl (5Z,8Z,11Z,14Z,17Z-eicosapentaenoate)
Cholest-5-en-3-ol (3β)-, 3-[(5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoate]
[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate | [Molecular Formula]
C47H74O2 | [MDL Number]
MFCD32201038 | [MOL File]
74892-97-0.mol | [Molecular Weight]
671.09 |
| Chemical Properties | Back Directory | [Boiling point ]
697.2±54.0 °C(Predicted) | [density ]
0.97±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: 10 mg/ml | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Cholesteryl eicosapentaenoate is a cholesterol ester. It induces cytotoxicity in human monocyte-macrophages in a concentration-dependent manner at concentrations ranging from 88 to 880 μM. Cholesteryl eicosapentaenoate levels are elevated 1.89-fold in the serum of pediatric patients with extrahepatic biliary atresia and decreased in the serum and plasma of patients with Alzheimer’s disease and abetalipoproteinemia, respectively, compared with healthy individuals. | [Uses]
CE(20:5(5Z,8Z,11Z,14Z,17Z) is an endogenous metabolite. | [Definition]
ChEBI: A cholesterol ester obtained by the formal condensation of cholesterol with all-cis-5,8,11,14,17-icosapentaenoic acid. | [IC 50]
Human Endogenous Metabolite | [References]
[1] S J HARDWICK. Toxicity of polyunsaturated fatty acid esters for human monocyte-macrophages: the anomalous behaviour of cholesteryl linolenate.[J]. Free Radical Research, 1997, 26 4: 351-362. DOI: 10.3109/10715769709097815
[2] E. ROBBERECHT A. C B Koletzko. Several mechanisms contribute to the abnormal fatty acid composition of serum phospholipids and cholesterol esters in cholestatic children with extrahepatic biliary atresia[J]. Prostaglandins, leukotrienes, and essential fatty acids, 1997, 56 3: Pages 199-204. DOI: 10.1016/s0952-3278(97)90534-2
[3] A M TULLY. Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer’s disease: a case-control study.[J]. British Journal of Nutrition, 2003, 89 4: 483-489. DOI: 10.1079/bjn2002804
[4] P V SUBBAIAH. Molecular species of cholesteryl esters formed in abetalipoproteinemia: effect of apoprotein B-containing lipoproteins.[J]. Journal of Lipid Research, 1990, 31 5: 927-932.
|
|
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|