| Identification | More | [Name]
4-Amidinophenylmethanesulfonyl fluoride hydrochloride | [CAS]
74938-88-8 | [Synonyms]
4-AMIDINOBENZYLSULFONYL FLUORIDE HYDROCHLORIDE
(4-AMIDINOPHENYL)METHANESULFONYL FLUORIDE
4-AMIDINOPHENYLMETHANESULFONYL-FLUORIDE-HCL
4-AMIDINOPHENYLMETHANE-SULFONYL FLUORIDE HYDROCHLORIDE
4-AMIDINOPHENYLMETHANESULPHONYL FLUORIDE
4-AMIDINOPHENYLMETHANESULPHONYL FLUORIDE HYDROCHLORIDE
4-APMSF
APMSF HCL
APMSF HYDROCHLORIDE
(P-AMIDINOPHENYL)METHANESULFONYL FLUORIDE HYDROCHLORIDE
P-AMIDINOPHENYLMETHYLSULFONYLFLUORIDE, HCL
P-AMIDINOPHENYLMETHYL-SULFONYLFLUORIDE HYDROCHLORIDE
P-APMSF
P-APMSF, HYDROCHLORIDE
4-AMIDINOPHENYLMETHANESULFONYL FLUORIDE HYDROCHLORI
4-AMIDINOPHENYLMETHANESULFONYL FLUORIDE HYDROCHLORIDE BIOCHEMIKA 97%
4-Amidinobenzylsulfonyl fluoride hydrochloride, p-APMSF | [Molecular Formula]
C8H10ClFN2O2S | [MDL Number]
MFCD00036898 | [Molecular Weight]
252.69 | [MOL File]
74938-88-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
~205 °C (dec.) | [storage temp. ]
−20°C
| [solubility ]
H2O: 50 mM Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.
| [form ]
White solid | [color ]
white | [Water Solubility ]
water: 25mg/mL | [BRN ]
9083148 | [InChIKey]
KHLLRHIUKOJXLL-UHFFFAOYSA-N | [CAS DataBase Reference]
74938-88-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [F ]
10-21 | [HS Code ]
29252900 |
| Hazard Information | Back Directory | [Description]
p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively.1 It is selective for these proteases over bovine chymotrypsin and acetylcholinesterase. | [Uses]
p-APMSF is an irreversible inhibitor of serinase. p-APMSF
has substrate specificity for positively charged side chains of amino acids,
lysine, or arginine. p-APMSF can be used to study the irreversible inhibition
of trypsin and thrombin [1]. | [Biochem/physiol Actions]
Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases. | [storage]
Store at -20°C | [References]
[1] Laura
R, et al. (p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitor
of serine proteases. Biochemistry. 1980 Oct 14;19(21):4859-64. DOI:10.1021/bi00562a024 |
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