| Identification | More | [Name]
2-(1H-PYRAZOL-3-YL)PYRIDINE | [CAS]
75415-03-1 | [Synonyms]
2-(1H-PYRAZOL-3-YL)PYRIDINE
BUTTPARK 17\04-92 | [Molecular Formula]
C8H7N3 | [MDL Number]
MFCD00115151 | [Molecular Weight]
145.16 | [MOL File]
75415-03-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
119-120°C | [Boiling point ]
362.2±17.0 °C(Predicted) | [density ]
1.214±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
11.36±0.10(Predicted) | [color ]
White to Light yellow | [λmax]
303nm(CH3CN aq.)(lit.) | [InChI]
InChI=1S/C8H7N3/c1-2-5-9-7(3-1)8-4-6-10-11-8/h1-6H,(H,10,11) | [InChIKey]
HKEWOTUTAYJWQJ-UHFFFAOYSA-N | [SMILES]
C1(C2C=CNN=2)=NC=CC=C1 | [CAS DataBase Reference]
75415-03-1(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
2-(1H-pyrazol-3-yl)pyridine is an organic intermediate that can be used to prepare a pyrazolidine alcohol-copper complex. This complex is a mononuclear Cu complex and exhibits antitumor activity. |
| Hazard Information | Back Directory | [Synthesis]
Example 15 Synthesis of 2-(1H-pyrazol-3-yl)pyridine (17a): compound 16a (1 g, 6.2 mmol) was dissolved with hydrazine hydrate (2 mL) in ethanol (3.3 mL) and reacted at 60°C for 0.5 hrs. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently removed under vacuum to afford the pale yellow solid product 17a (874.7 mg) in 97.3% yield.1H-NMR (400 MHz, CDCl3): δ 8.66 (d, J = 4.8 Hz, 1H), 7.75 (d, J = 3.6 Hz, 2H), 7.67 (d, J = 2Hz, 1H), 7.23-7.27 (m, 1H), 6.81 (d, J = 2Hz, 1H). | [References]
[1] Patent: US2014/142144, 2014, A1. Location in patent: Paragraph 0235; 0236; 0237
[2] Patent: EP2738169, 2014, A1. Location in patent: Paragraph 0105; 0106; 0107
[3] Journal of the Chemical Society, Chemical Communications, 1994, # 24, p. 2751 - 2752
[4] European Journal of Inorganic Chemistry, 2007, # 26, p. 4197 - 4206 |
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