| Identification | Back Directory | [Name]
Kaerophyllin | [CAS]
75590-33-9 | [Synonyms]
Kaerophyllin
Chaerophyllin
(-)-Kaerophylin
2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)-3-[(3,4-dimethoxyphenyl)methylene]dihydro-, (3E,4R)- | [Molecular Formula]
C21H20O6 | [MDL Number]
MFCD20274730 | [MOL File]
75590-33-9.mol | [Molecular Weight]
368.38 |
| Hazard Information | Back Directory | [Description]
Kaerophyllin can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting HSC activation, possibly through upregulation of PPAR-γ expression.
Kaerophyllin inhibits AB-induced LX-2 activation and migration with downregulation of Akt/ERK phosphorylations and NF-κB activity. | [Uses]
Kaerophyllin ((-)-Kaerophylin) is a lignan that can be found in Chaerophyllum maculatum[1]. | [target]
TNF-α | PPAR | Akt | ERK | NF-kB | IL Receptor | [References]
[1] Mikaya GA, et al. Kaerophyllin, a new lignan from Chaerophyllum maculatum. Planta Med. 1981 Dec;43(4):378-80. DOI:10.1055/s-2007-971527 |
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