| Identification | Back Directory | [Name]
HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL | [CAS]
75614-89-0 | [Synonyms]
(R)()-α-Methylhistamine
R-(?)-α-Methylhistamine hydrochloride
R-()-α-Methylhistamine (hydrochloride)
HISTAMINE DIHYDROCHLORIDE R(-)-A-METHYL
R(-)-α-Methyl Histamine Dihydrochloride
(R)-1-(1H-Imidazol-4-yl)propan-2-amine dihydrochloride
(R)-2-(1H-Imidazol-4-yl)-1-methyl-ethylamine hydrochloride
R-(-)-2-(1H-Imidazol-4-yl)-1-methyl-ethylamine dihydrochloride
(R)()αMethylhistamine dihydrochloride,(R) ( ) α Methylhistamine dihydrochloride | [Molecular Formula]
C6H12ClN3 | [MDL Number]
MFCD00083176 | [MOL File]
75614-89-0.mol | [Molecular Weight]
161.63 |
| Chemical Properties | Back Directory | [Melting point ]
169-173°C | [storage temp. ]
desiccated | [solubility ]
H2O: soluble | [form ]
Powder | [color ]
white to off-white | [optical activity]
[α]22/D 4°, c = 0.8 in H2O(lit.) | [Water Solubility ]
H2O: soluble | [Sensitive ]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Potent, selective H3 histamine receptor agonist which crosses the blood-brain barrier; inhibits histamine synthesis and release.
| [Uses]
R(-)-α-Methyl Histamine Dihydrochloride is a potent and selective H3 histamine receptor agonist that inhibits the synthesis and release of histamine (1,2,3,4). R(-)-α-Methyl Histamine Dihydrochloride is a blood-brain barrier penetrant. | [Biochem/physiol Actions]
Potent, selective H3 histamine receptor agonist which crosses the blood-brain barrier; inhibits histamine synthesis and release. | [in vivo]
Pretreatment with (R)-(-)-α-Methylhistamine dihydrochloride (RAMH; 10 mg/kg; i.p.; 60 min before training) reverses Propofol‐induced (25 mg/kg; i.p.; 30 min before training) memory retention[5].
?
(R)-(-)-α-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[3].
| Animal Model: | Male Sprague‐Dawley rats (10-12 week)[3] | | Dosage: | 10 mg/kg | | Administration: | IP; 60 min before training | | Result: | Reversed propofol‐induced memory retention.
|
| [IC 50]
H3 receptor: 50.3 nM (Kd) |
|
| Company Name: |
SynAsst Chemical.
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| Tel: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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