| Identification | Back Directory | [Name]
(+)-Biotin-PEG4-Hydrazide | [CAS]
756525-97-0 | [Synonyms]
4-hydrazide
Biotin-dPEG®
Biotin-dPEG??-hydrazide
(+)-Biotin-PEG4-Hydrazide
Biotin-dPEG(R)4-hydrazide
(+)-Biotin-PEG4-Hydrazide
Biotin-PEG4-Propinonic hydrazide
15-(Biotinamido)-4,7,10,13-tetraoxapentadecanehydrazide
N-[2-[2-[2-[2-(3-Hydrazinyl-3-oxopropoxy)ethoxy]ethoxy]ethoxy]ethyl]biotinamide
4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-, hydrazide | [Molecular Formula]
C21H39N5O7S | [MDL Number]
MFCD09952658 | [MOL File]
756525-97-0.mol | [Molecular Weight]
505.63 |
| Chemical Properties | Back Directory | [Boiling point ]
825.5±65.0 °C(Predicted) | [density ]
1.201±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
solid or viscous liquid | [pka]
12.82±0.35(Predicted) | [color ]
White to Light yellow | [InChIKey]
PSBJJOWIACLJAQ-UHFFFAOYSA-N | [SMILES]
O=C(CCOCCOCCOCCOCCNC(CCCCC1SCC(C1N2)NC2=O)=O)NN |
| Hazard Information | Back Directory | [Description]
Biotin-PEG4-hydrazide is a biotinylation reagent that can be used to label glycoproteins, carbohydrate-containing compounds that have oxidizable sugars or aldehydes. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds. The hydrophilic PEG arm imparts water solubility that is transferred to the biotinylated molecule. | [Uses]
Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reagent type: cross-linking reagent
reaction type: Biotinylations
reactivity: carbonyl reactive | [IC 50]
PEGs | [References]
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329 |
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