| Identification | Back Directory | [Name]
FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID | [CAS]
557756-85-1 | [Synonyms]
FMOC-15-AMINO-4
FmocNH-PEG5-acid
Fmoc-NH-PEG4-COOH
Fmoc-NH-PEG4c-COOH
Fmoc-NH-(PEG)3-COOH
Fmoc-PEG4- CH2CH2COOH
Fmoc-N-amido-PEG4-acid
Moc-NH-PEG3-CH2CH2COOH
FMoc-NH-PEG4-CH2CH2COOH
Fmoc-PEG4-propionic acid
Fmoc-N-amido-dPEG(R)4-acid
13-TETRAOXAPENTADECANOIC ACID
FMOC-AMINO-PEG4-PROPANOIC ACID
FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID
FMoc-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid
15-(Fmoc-amino)-4,7,10,13-tetraoxapentadecanoic Acid
Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid≥ 97% (HPLC)
1-(9H-Fluoren-9-yl)-3-oxo-2,7,1,13,16-pentaoxa-4-azanonadecan-19-oic acid
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oic acid
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,6,9,12-tetraoxapentadecan-15-oic acid
Fmoc-PEG4-OH
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oic acid
3-[2-[2-[2-[2-(9H-fluoren-9-ylMethoxycarbonylaMino)ethoxy]ethoxy]ethoxy]ethoxy]propanoicacid
3-[2-[2-[2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propionic acid | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C26H33NO8 | [MDL Number]
MFCD06656472 | [MOL File]
557756-85-1.mol | [Molecular Weight]
487.54 |
| Chemical Properties | Back Directory | [Boiling point ]
682.1±55.0 °C(Predicted) | [density ]
1.219 | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
solid or viscous liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C26H33NO8/c28-25(29)9-11-31-13-15-33-17-18-34-16-14-32-12-10-27-26(30)35-19-24-22-7-3-1-5-20(22)21-6-2-4-8-23(21)24/h1-8,24H,9-19H2,(H,27,30)(H,28,29) | [InChIKey]
NUHRPLKTAAVHCZ-UHFFFAOYSA-N | [SMILES]
C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCCOCCOCCOCCOCCC(O)=O |
| Hazard Information | Back Directory | [Description]
Fmoc-N-amido-PEG4-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Chemical Properties]
Yellow oil | [Uses]
Fmoc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Application]
Fmoc-NH-PEG4-CH₂CH₂COOH (CAS 557756-85-1) is a high-purity (＞98%) hetero-bifunctional PEG linker. Its synonyms include Fmoc-N-amido-PEG4-acid, Fmoc-PEG4-propionic acid and 4-propionic acid. This substance can be used in drug delivery systems, hydrogel systems, and the synthesis of ADCs and PROTACs, amongst other applications. | [reaction suitability]
reaction type: Pegylations
reagent type: cross-linking reagent | [IC 50]
Cleavable Linker; PEGs | [References]
[1] Cai P, et al. Synthesis of C3-Alkylated Indoles on DNA via Indolyl Alcohol Formation Followed by Metal-FreeTransfer Hydrogenation. Org Lett. 2019 Aug 14. DOI:10.1021/acs.orglett.9b02132 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
T&W GROUP
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| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
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