| Identification | Back Directory | [Name]
FOLIC ACID DIHYDRATE | [CAS]
75708-92-8 | [Synonyms]
PGA DIHYDRATE
FolicAcidB.P.
FOLIC ACID pure
PTEROYLGLUTAMIC ACID
FOLIC ACID DIHYDRATE
FOLIC ACID, 500MG, NEAT
VitaMin M or VitaMin Bc
FOLIC ACID DIHYDRATE 97%
PGA, Pteroylglutamic acid
PTEROYLGLUTAMIC ACID DIHYDRATE
Folic acid dihydrate, PGA, Pteroylglutamic acid
L-Glutamic acid, N-4-(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methylaminobenzoyl-, dihydrate | [EINECS(EC#)]
200-419-0 | [Molecular Formula]
C19H23N7O8 | [MDL Number]
MFCD00150769 | [MOL File]
75708-92-8.mol | [Molecular Weight]
477.43 |
| Chemical Properties | Back Directory | [Appearance]
Yellow to yellow-orange crystalline powd | [Melting point ]
250°C | [storage temp. ]
Store at RT. | [solubility ]
Aqueous Acid (Slightly), Aqueous Base (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
pK1:8.26 (25°C) | [color ]
Yellow to Dark Yellow | [Water Solubility ]
Miscible with water. | [Merck ]
14,4221 | [BRN ]
100781 | [CAS DataBase Reference]
75708-92-8 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow to yellow-orange crystalline powd | [Uses]
Vitamin B9. A B-complex vitamin necessary for the body to produce red blood cellsFolic acid dehydrate is used to form non-covalent complexes with polyethylenimine. It is used for the delivery of genes, which finds application in gene therapy. It is a B-complex vitamin, which is necessary for the body to produce red blood cells. | [Purification Methods]
If paper chromatography indicates impurities, then recrystallise it from hot H2O or from dilute acid [Walker et al. J Am Chem Soc 70 19 1948]. Impurities may be removed by repeated extraction with n-BuOH of a neutral aqueous solution of folic acid (by suspending in H2O and adding N NaOH dropwise till the solid dissolves, then adjusting the pH to ~7.0-7.5) followed by precipitation with acid, filtration, or better collected by centrifugation and recrystallised form hot H2O. [Blakley Biochem J 65 331 1975, Kalifa et al. Helv Chim Acta 6 1 2739 1978.] Chromatography on cellulose followed by filtration through charcoal has also been used to obtain pure acid. [Sakami & Knowles Science 129 274 1959.] UV: max 247 and 296nm ( 12,800 and 18,700) in H2O pH 1.0; 282 and 346nm ( 27.600 and 7,200) in H2O pH 7.0; 256, 284 and 366nm ( 24600, 24,500 and 86,00) in H2O pH 13 [Rabinowitz in The Enzymes (Boyer et al. Eds), 2 185 1960]. [Beilstein 26 III/IV 3944.] |
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