| Identification | More | [Name]
HNE | [CAS]
75899-68-2 | [Synonyms]
HNE
4-HNE
Ccris 1781
4-HYDROXYNONENAL
4-hydroxy-2-nonena
4-HYDROXY-2-NONENAL
(E)-4-HYDROXYNONENAL
(E)-4-hydroxynon-2-enal
HNE ISO 9001：2015 REACH
(+/-)-4-HYDROXYNON-2-ENAL
(+/-)-4-HYDROXY-2E-NONENAL
2-Nonenal, 4-hydroxy-, (2E)-
Mouse 4-Hydroxy-2-nonenal elisa kit | [Molecular Formula]
C9H16O2 | [MDL Number]
MFCD00211020 | [Molecular Weight]
156.22 | [MOL File]
75899-68-2.mol |
| Chemical Properties | Back Directory | [Boiling point ]
125-127 °C(Press: 2 Torr) | [density ]
0.941±0.06 g/cm3(Predicted) | [storage temp. ]
-70°C | [solubility ]
DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml | [form ]
Colorless oil. | [pka]
13.31±0.20(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+ | [InChIKey]
JVJFIQYAHPMBBX-FNORWQNLSA-N | [SMILES]
C(=O)/C=C/C(O)CCCCC | [CAS DataBase Reference]
75899-68-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 μM.[Cayman Chemical]
| [Definition]
ChEBI:4-hydroxynon-2-enal is an enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position. It has a role as a human metabolite. It is a hydroxyaldehyde, an enal and a 4-hydroxynonenal. | [Biological Activity]
Primary Target
Na+K+-ATPase activity''Product does not compete with ATP.''Target IC50: 120 μM against Na+K+-ATPase activity | [in vivo]
Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2+/+) and Nrf2-deficient mice (Nrf2-/-) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2+/+ and Nrf2-/- mice. Similar to iNOS result, in Nrf2-/- KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2+/+ WT animals[2]. | [IC 50]
ALDH2; Human Endogenous Metabolite | [storage]
Store at -80°C,protect from light |
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