| Identification | Back Directory | [Name]
Pafenolol | [CAS]
75949-61-0 | [Synonyms]
H-138/03
Pafenolol
rac-(R*)-1-(Isopropylamino)-3-[4-[2-(3-isopropylureido)ethyl]phenoxy]-2-propanol
Urea, N-[2-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]ethyl]-N'-(1-methylethyl)- | [Molecular Formula]
C18H31N3O3 | [MOL File]
75949-61-0.mol | [Molecular Weight]
337.46 |
| Hazard Information | Back Directory | [Uses]
Pafenolol is a selectively oral-active β1 adrenergic receptor (β1-adrenergic receptor) antagonist that effectively lowers blood pressure. Pharmacokinetic studies in rats indicate that the absorption of Pafenolol is influenced by gastrointestinal contents, with food intake reducing the bioavailability of Pafenolol in rats. Pafenolol can be used in research related to cardiovascular diseases and asthma[1]. | [IC 50]
Beta-1 adrenergic receptor | [References]
[1] Sigurdsson J A, et al. Pafenolol, a new β 1-selective blocking agent, in mild hypertension. Result of an inpatient study and a subsequent outpatient follow-up[J]. European journal of clinical pharmacology, 1984, 26: 549-553. DOI:10.1007/BF00543483 |
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