ChemicalBook--->CAS DataBase List--->7599-79-3

7599-79-3

7599-79-3 Structure

7599-79-3 Structure
IdentificationBack Directory
[Name]

trans-clomifene citrate
[CAS]

7599-79-3
[Synonyms]

Androxal
Enclomid
Unii-J303A6U9Y6
Enclomifene citrate
Clomiphene B citrate
Enclomiphene citrate
(E)-Clomiphene citrate
trans-clomifene citrate
trans-Clomiphene citrate
Enclomiphene Citrate /trans-Clomiphene
Triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)-, citrate, (E)-
[EINECS(EC#)]

-0
[Molecular Formula]

C32H36ClNO8
[MDL Number]

MFCD00058322
[MOL File]

7599-79-3.mol
[Molecular Weight]

598.083
Chemical PropertiesBack Directory
[Melting point ]

143-145°C
[storage temp. ]

Amber Vial, -20°C Freezer
[solubility ]

DMSO (Slightly), Ethyl Acetate (Slightly, Heated, Sonicated)
[form ]

Solid
[color ]

White to Off-White
[Stability:]

Light Sensitive
[InChIKey]

PYTMYKVIJXPNBD-BTKVJIOYSA-N
Safety DataBack Directory
[Symbol(GHS) ]


GHS08
[Signal word ]

Danger
[Hazard statements ]

H360
Hazard InformationBack Directory
[Uses]

trans-Clomiphene Citrate, stereoisomer of Clomiphene Citrate (C587025), a synthetic estrogen agonist-antagonist. Gonad-stimulating principle.
[Toxicology]

The effects of the cis and trans isomers of clomiphene citrate on the uterine hexokinase activity of immature ovariectomized rats were studied in long- and short-term experiments. At a dose level of 600 μg/kg, both trans-Clomiphene Citrate and cis-Clomiphene Citrate caused a similar increase in total uterine hexokinase activity observable in 18 hr. When enzyme activity was expressed per g of the uterus (specific activity), significant increases were noted 18 hr after a single injection of trans clomiphene or after 4 daily injections of either isomer. Treatment of these animals with 170-estradiol (5 μg/kg) caused an elevation of both the specific and total hexokinase activities within 18 hr[1].
[in vivo]

Enclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats[5].
Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol[6].

Animal Model:21 days-old Charles River male rats[5]
Dosage:0.25 and 0.5 mg/animal, daily for 24 days.
Administration:Subcutaneous injection
Result:Decreased LH and testosterone levels in the serum.
Animal Model:OVX (ovariectomy) rat model[6]
Dosage:0.03, 1, and 3 mg/kg, daily for 90 days.
Administration:Oral adminstration
Result:Reducted body weight to sham levels, and reduced serum cholesterol.
Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
[References]

[1] D L DiPietro, D A Goss, F J Sanders. “Effect of cis and trans isomers of clomiphene citrate on uterine hexokinase activity.” Endocrinology 84 6 (1969): 1404–8.
Spectrum DetailBack Directory
[Spectrum Detail]

trans-clomifene citrate(7599-79-3)1HNMR
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