| Identification | Back Directory | [Name]
Derrone | [CAS]
76166-59-1 | [Synonyms]
Derrone
5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
3-(4-Hydroxyphenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl- | [Molecular Formula]
C20H16O5 | [MDL Number]
MFCD22417277 | [MOL File]
76166-59-1.mol | [Molecular Weight]
336.34 |
| Chemical Properties | Back Directory | [Boiling point ]
584.1±50.0 °C(Predicted) | [density ]
1.368±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
6.47±0.40(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity[1][2]. | [target]
Antifection | [References]
[1] Hoang NT, et al. In Vitro Characterization of Derrone as an Aurora Kinase Inhibitor. Biol Pharm Bull. 2016 Jun 1;39(6):935-45. DOI:10.1248/bpb.b15-00835
[2] Kang MJ, et al. Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells. PLoS One. 2019 Jun 19;14(6):e0218659. DOI:10.1371/journal.pone.0218659 |
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