| Identification | Back Directory | [Name]
XR9051 | [CAS]
762219-35-2 | [Synonyms]
XR9051
3-[(Z)-[(5Z)-5-benzylidene-4-methyl-3,6-dioxopiperazin-2-ylidene]methyl]-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]benzamide | [Molecular Formula]
C39H38N4O5 | [MDL Number]
MFCD26960892 | [MOL File]
762219-35-2.mol | [Molecular Weight]
642.74 |
| Hazard Information | Back Directory | [Description]
XR9051 is as a potent modulator of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) following a synthetic chemistry programme based on a natural product lead compound. XR9051 was shown to be a potent inhibitor of the binding of the cytotoxic to P-glycoprotein (EC50 = 1.4 +/- 0.5 nM). XR9051 reverses the MDR phenotype through direct interaction with P-glycoprotein. |
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