762219-35-2

英文名称 XR9051

CAS 762219-35-2

分子式 C39H38N4O5

分子量 642.74

MOL 文件 762219-35-2.mol

762219-35-2 结构式

基本信息应用领域常见问题列表

基本信息

英文别名

XR9051
3-[(Z)-[(5Z)-5-benzylidene-4-methyl-3,6-dioxopiperazin-2-ylidene]methyl]-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]benzamide

应用领域

用途一

XR9051 is as a potent modulator of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) following a synthetic chemistry programme based on a natural product lead compound. XR9051 was shown to be a potent inhibitor of the binding of the cytotoxic to P-glycoprotein (EC50 = 1.4 +/- 0.5 nM). XR9051 reverses the MDR phenotype through direct interaction with P-glycoprotein.

常见问题列表

概述

XR9051 口服有效的、特异性的 P-糖蛋白介导的多药耐药特异性调节剂。