| Identification | Back Directory | [Name]
KP 136 | [CAS]
76239-32-2 | [Synonyms]
KP 136
AL-136
8-(Hexyloxy)-3-(1H-tetrazol-5-yl)coumarin
8-(Hexyloxy)-3-(1H-tetrazol-5-yl)-2H-1-benzopyran-2-one
2H-1-Benzopyran-2-one, 8-(hexyloxy)-3-(2H-tetrazol-5-yl)- | [Molecular Formula]
C16H18N4O3 | [MDL Number]
MFCD01762843 | [MOL File]
76239-32-2.mol | [Molecular Weight]
314.34 |
| Hazard Information | Back Directory | [Uses]
KP136 (AL136) is an orally effective antiallergic agent. The IC50 is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation[1]. | [in vivo]
C4C at 0.2 mg/kg produces an equipotent effect to 1 mg/kg KP136 (KP-136) or 5 mg/kg DSCG. However, C4C is less effective by the oral route because it only produces a maximum inhibition of about 35% even at the high dose of 100 mg/kg, whereas KP136 shows an overt inhibitory effect of about 66% at the oral dose of 2 mg/kg. On the other hand, KP136 (1 mg/kg, i.v.) also remarkably inhibits 5-h homologous PCA, having an activity similar to that of C4C[1]. | [References]
[1] Kuriyama K, et al. Antiallergic effects of 4-[2-oxo-3-(1H-tetrazol-5-yl)-2H-chromen-8-yloxy]-bu tyric acid. Jpn J Pharmacol. 1989 Jun;50(2):111-8. DOI:10.1254/jjp.50.111 |
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