| Identification | Back Directory | [Name]
N-[N-[N-(3-Hydroxy-4-methyl-1-oxodecyl)-L-tryptophyl]-L-phenylalanyl]-D-alloisoleucine λ-lactone | [CAS]
76265-42-4 | [Synonyms]
Beauverolide Ka
N-[N-[N-(3-Hydroxy-4-methyl-1-oxodecyl)-L-tryptophyl]-L-phenylalanyl]-D-alloisoleucine λ-lactone | [Molecular Formula]
C37H50N4O5 | [MOL File]
76265-42-4.mol | [Molecular Weight]
630.817 |
| Hazard Information | Back Directory | [Uses]
Beauverolide Ka, a cyclotetradepsipeptide, is a metabolite of Beauveria bassiana fungus. Beauverolide Ka stimulates glucose uptake in cultured rat L6 myoblasts at 50 μM. Beauverolide Ka exhibits protecting effects on HEI-OC1 cells at 10 μM and shows dose-dependent activity in both L6 myoblasts and myotubes[1][2]. | [IC 50]
Fungal Metabolite | [References]
[1] Yuan-Fei Zhou, et al. 3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp. J Nat Prod. 2021 Apr 23;84(4):1244-1253. DOI:10.1021/acs.jnatprod.0c01305
[2] Feifei Luo, et al. Differential metabolic responses of Beauveria bassiana cultured in pupae extracts, root exudates and its interactions with insect and plant. J Invertebr Pathol. 2015 Sep;130:154-64. DOI:10.1016/j.jip.2015.01.003 |
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