| Identification | Back Directory | [Name]
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide | [CAS]
765317-72-4 | [Synonyms]
PTP1B-IN-4
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide
6-BenzofuransulfonaMide, 3-(3,5-dibroMo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylaMino)sulfonyl]phenyl]-
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide | [Molecular Formula]
C26H19Br2N3O7S3 | [MDL Number]
MFCD09037556 | [MOL File]
765317-72-4.mol | [Molecular Weight]
741.45 |
| Chemical Properties | Back Directory | [Boiling point ]
855.0±75.0 °C(Predicted) | [density ]
1.812±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light | [solubility ]
Soluble in ethanol and DMSO | [form ]
Solid | [pka]
4.47±0.25(Predicted) | [color ]
White to off-white | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Description]
Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer. PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 μM for 403 and 298 residue PTP1B forms, respectively). It binds reversibly and non-competitively, altering the conformation of the catalytic pocket. PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin. | [Uses]
PTP1B Inhibitor is used as a PTP1B inhibitor blocks the activity of the Protein Tyrosine Phosphatase 1B, which is a key factor in the negative regulation of insulin and leptin signaling pathway. Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer. | [storage]
Store at -20°C, protect from light | [References]
[1] SHENG ZHANG Zhong Y Z. PTP1B as a drug target: recent developments in PTP1B inhibitor discovery.[J]. Drug Discovery Today, 2007, 12 9-10: 373-381. DOI: 10.1016/j.drudis.2007.03.011
[2] TONKS N K. Protein tyrosine phosphatases – from housekeeping enzymes to master regulators of signal transduction[J]. The FEBS journal, 2012, 280 2: 346-378. DOI: 10.1111/febs.12077
[3] CHRISTIAN WIESMANN. Allosteric inhibition of protein tyrosine phosphatase 1B[J]. Nature Structural & Molecular Biology, 2004, 11 8: 730-737. DOI: 10.1038/nsmb803
[4] SHUAI LI. The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B.[J]. ACS Applied Bio Materials, 2014: e97668. DOI: 10.1371/journal.pone.0097668 |
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China Langchem Inc.
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SynAsst Chemical.
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SPIRO PHARMA
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Energy Chemical
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cjbscvictory
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Bide Pharmatech Ltd.
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