| Identification | Back Directory | [Name]
RONIDAZOLE | [CAS]
7681-76-7 | [Synonyms]
MCMN
dugro
Dufro
ridzol
ridzolp
Ridzole
ridazole
RONIDAZOL
Ronida BT
Aids039582
RONIDAZOLE
Aids-039582
TIMTEC-BB SBB006916
RONIDAZOLE STANDARD
ronidazol-pharmachim
ronidazole Solution, 100ppm
Ridzol (Merck,Sharp & Dohme)
1-methyl-5-nitroimidazol-2-ylmethyl carbamate
1-METHYL-2-[CARBAMOYLOXYMETHYL]-5-NITROIMIDAZOLE
1-Methyl-5-nitro-1H-imidazole-2-methanol carbamate
(1-Methyl-5-nitro-1H-iMidazol-2-yl)Methyl carbaMate
1-Methyl-5-nitro-1H-iMidazole-2-Methanol 2-CarbaMate
1-methyl-5-nitro-imidazole-2-methanocarbamate(ester)
1-methyl-5-nitro-1h-imidazole-2-methanolcarbamateester
1H-IMidazole-2-Methanol,1-Methyl-5-nitro-, 2-carbaMate
1-methyl-5-nitro-1h-imidazole-2-methanocarbamate(ester)
Carbamic acid (1-methyl-5-nitro-1H-imidazol-2-yl)methyl
Carbamic acid (1-methyl-5-nitro-1H-imidazol-2-yl)methyl ester
1H-Imidazole-2-methanol, 1-methyl-5-nitro-, carbamate (ester) | [EINECS(EC#)]
231-675-1 | [Molecular Formula]
C6H8N4O4 | [MDL Number]
MFCD00133801 | [MOL File]
7681-76-7.mol | [Molecular Weight]
200.15 |
| Chemical Properties | Back Directory | [Melting point ]
167-169° | [Boiling point ]
337.86°C (rough estimate) | [density ]
1.5359 (rough estimate) | [refractive index ]
1.6500 (estimate) | [storage temp. ]
−20°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
neat | [pka]
1.2(at 25℃) | [color ]
Pale Yellow | [Major Application]
forensics and toxicology
pharmaceutical (small molecule)
veterinary | [InChI]
InChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11) | [InChIKey]
PQFRTXSWDXZRRS-UHFFFAOYSA-N | [SMILES]
C1(COC(=O)N)=NC=C([N+]([O-])=O)N1C |
| Hazard Information | Back Directory | [Uses]
antibacterial | [Uses]
Antimicrobial. | [Definition]
ChEBI: Ronidazole is a carbamate ester that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl and (carbamoyloxy)methyl groups, respectively. An antiprotozoal agent, it is used in veterinary medicine for the treatment of histomoniasis and swine dysentery. It has a role as an antiprotozoal drug and an antiparasitic agent. It is a member of imidazoles, a carbamate ester and a C-nitro compound. | [Veterinary Drugs and Treatments]
Ronidazole is a nitroimidazole antibiotic/antiparasitic drug that
appears to be useful in treating Tritrichomonas foetus infections in
cats. The drug is not commercially available in the USA and must
be compounded from bulk powder by a compounding pharmacy.
The drug is also used for treating Trichomonas infections in nonfood
animal birds. | [in vivo]
Pharmacokinetic Analysis in six cats[3]
| Drug administration | Dose (mg/kg) | T1/2 (K) (h) | C0 (μg/mL) | AUC 0-∞ (h?μg/m) | Vd or Vd/F (mL/kg) | Clearance or CL/F (h) | MRT (h) | Tmax (h) | Cmax (μg/m) | F (%) | Dose (mg/kg) Time (h) AUClast Cmax (ng/mL)
| i.v. | 9.175 | 9.80 | 13.27 | 187.30 | 700 | 0.82 | 14.14 | NA | NA | NA | | p.o. | 28.23 | 10.50 | NA | 566.98 | 770 | 0.84 | NA | 1.02 | 35.37 | 99.64 |
| Animal Model: | CDI mice model[2] | | Dosage: | 1 mg/kg, 10mg/kg | | Administration: | Oral gavage | | Result: | Both 1 mg/kg and 10 mg/kg Ronidazole protected 60% of mice from infection |
|
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
|