| Identification | Back Directory | [Name]
Przewaquinone A | [CAS]
76843-23-7 | [Synonyms]
Przewaquinone A
6,7,8,9-Tetrahydro-1-(hydroxymethyl)-6,6-dimethylphenanthro[1,2-b]furan-10,11-dione
1-(hydroxymethyl)-6,6-dimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1-(hydroxymethyl)-6,6-dimethyl- | [Molecular Formula]
C19H18O4 | [MDL Number]
MFCD21333242 | [MOL File]
76843-23-7.mol | [Molecular Weight]
310.34 |
| Chemical Properties | Back Directory | [Melting point ]
171-173℃ | [Boiling point ]
430.4±40.0 °C(Predicted) | [density ]
1.288±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
13.19±0.10(Predicted) | [color ]
Red |
| Hazard Information | Back Directory | [Uses]
Przewaquinone A, a lipophilic diterpene quinone present only in Salvia przewalskii, induces a potent inhibitory action on vascular contraction[1]. | [Cytotoxicity]
IC50 (μg/mL): 0.77 (5637), 1.73 (A-427),0.34 (MCF-7) (Mothana et al. 2009)
IC50 (μg/mL): 2.3 (Hep-2), 1.7 (A549), 1.9(SK-OV-3), 1.6 (SK-MEL-2) 0.8 (XF498)(Wang et al. 2007), IC50 (μg/mL): 23(P-388) (Zhao et al. 2011)
IC50 (μg/mL): 2.3 (A549), 1.7 (SK-OV-3),1.9 (SK-MEL-2), 1.96 (XF498), 0.8(HCT15) (Zhang et al. 2013) | [References]
[1] Alan K S Wan, et al. Vascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary artery. J Nat Prod. 2008 Nov;71(11):1825-8. DOI:10.1021/np800119k |
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