ChemicalBook--->CAS DataBase List--->76849-19-9

76849-19-9

76849-19-9 Structure

76849-19-9 Structure
IdentificationBack Directory
[Name]

CB 3717
[CAS]

76849-19-9
[Synonyms]

PDDF
CB 3717
8-dideazafolic acid
N(sup 10)-Propargyl-5
LTKHPMDRMUCUEB-IBGZPJMESA-N
10-Propargyl-5,8-dideazafolate
10-Propargyl-5,8-dideazafolic acid
N(sup 10)-Propargyl-5,8-dideazafolic acid
N10)-PROPARGYL-5,8-DIDEAZAFOLIC ACID
N-[p-[Propargyl(2-amino-4-hydroxyquinazolin-6-ylmethyl)amino]benzoyl]-L-glutamic acid
N-[4-[[(2-Amino-1,4-dihydro-4-oxoquinazolin-6-yl)methyl]-2-propynylamino]benzoyl]-L-glutamic acid
L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propyn-1-ylamino]benzoyl]-
[Molecular Formula]

C24H23N5O6
[MDL Number]

MFCD00869489
[MOL File]

76849-19-9.mol
[Molecular Weight]

477.475
Hazard InformationBack Directory
[Hazard]

A poison.
[Description]

CB 3717, a potent inhibitor of thymidylate synthase, is toxic for cell lines with altered dihydrofolate reductase; and homofolate, a de novo purine inhibitor requiring dihydrofolate reductase for activation, is effective in reductase-amplified lines.
[Uses]

CB 3717 is a potent inhibitor of human thymidylate synthetase, competitively binding with 5,10-methylenetetrahydrofolate (Ki = 4.9 X 10(-9) M). It also competitively inhibits human dihydrofolate reductase with dihydrofolate (Ki = 2.3 X 10(-8) M). In WI-L2 human lymphoblastoid cells, CB 3717 treatment led to a significant decrease in cellular dTTP levels and a notable increase in dUMP levels, indicating a disruption in nucleotide metabolism. The growth-inhibitory effect of CB 3717 was reversed by thymidine supplementation, demonstrating that thymidylate synthetase became rate-limiting in the presence of this compound. Delayed thymidine supplementation beyond 8 hours resulted in severe cytotoxicity, underscoring the critical timing of nucleotide rescue strategies in CB 3717-treated cells[1].
[Definition]

ChEBI: CB3717 is a N-acyl-L-glutamic acid.
[References]

[1] Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-(( 2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino) benzoyl)-L-glutamic acid (CB3717), on human lymphoblastoid cells DOI:10.1016/0006-2952(83)90150-8
76849-19-9 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: Hu Bei Jiutian Bio-medical Technology CO.,Ltd
Tel: 027-88013699 17354350817 , 17354350817
Website: www.jiutian-bio.com
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: SPIRO PHARMA  
Tel:
Website: www.spiropharma.com.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Tags:76849-19-9 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.