| Identification | Back Directory | [Name]
15-Methoxypinusolidic acid | [CAS]
769928-72-5 | [Synonyms]
15-methoxyconiferous acid
15-Methoxypinusolidic acid
(1S,4~{a}R,5S,8~{a}R)-5-[2-(2-methoxy-5-oxo-2~{H}-furan-4-yl)ethyl]-1,4~{a}-dimethyl-6-methylidene-3,4,5,7,8,8~{a}-hexahydro-2~{H}-naphthalene-1-carboxylic acid | [Molecular Formula]
C21H30O5 | [MDL Number]
MFCD20260775 | [MOL File]
769928-72-5.mol | [Molecular Weight]
362.46 |
| Hazard Information | Back Directory | [Description]
15-Methoxypinusolidic acid induced apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression.
15-Methoxypinusolidic acid inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB, suggesting a potential anti-inflammatory effect of the compound on microglial cells.
3. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression.
4. 15-Methoxypinusolidic acid attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors. | [target]
NOS | NO | PPAR | Calcium Channel | NF-kB | NMDAR | p38MAPK | ERK | JNK | IL Receptor | COX |
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BioBioPha Co., Ltd.
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0871-65217109 13211707573; |
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http://www.biobiopha.com |
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