| Identification | Back Directory | [Name]
SR 57227 HYDROCHLORIDE | [CAS]
77145-61-0 | [Synonyms]
cm57227
sr57227a
CM-57277
SR57227HCl
SR 57227 HYDROCHLORIDE
SR 57227A HYDROCHLORIDE
1-(6-CHLORO-2-PYRIDINYL)-4-PIPERIDINAMINE HYDROCHLORIDE
4-AMINO-1-(6-CHLORO-2-PYRIDYL)-PIPERIDINE HYDROCHLORIDE
1-(6-chloropyridin-2-yl)piperidin-4-amine hydrochloride
1-(6-chloro-2-pyridinyl)-4-piperidinaminmonohydrochloride
4-amino-1-(6-chloro-2-pyridyl)piperidinemonohydrochloride
1-(6-chloro-2-pyridinyl)-4-piperidinaminemonohydrochloride | [Molecular Formula]
C10H15Cl2N3 | [MDL Number]
MFCD01756430 | [MOL File]
77145-61-0.mol | [Molecular Weight]
248.15 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at RT | [solubility ]
H2O: 9 mg/mL, soluble
| [form ]
solid
| [color ]
white
| [Water Solubility ]
H2O: soluble 9mg/mL | [InChI]
1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H | [InChIKey]
FUMINTAAUJUVMP-UHFFFAOYSA-N | [SMILES]
Cl.NC1CCN(CC1)c2cccc(Cl)n2 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25-36/37/38 | [Safety Statements ]
26-45 | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
TM3465250
| [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
SR 57227A acts as highly potent and shows high affinity for the 5-HT3 receptor agonist. | [Biological Activity]
A high affinity, selective 5-HT 3 receptor agonist, active in vivo and CNS penetrant. | [in vivo]
SR 57227A (1-30 mg/kg; i.p.) dose-dependently reduces immobility time in the forced swimming test with an ED50 value for this effect of 14.2 mg/kg[2].
In the forced swimming test, SR 57227A dose-dependently reduces the duration of immobility in rats after i.p. administration. (ED50=7.6 mg/kg i.p. in rats.) SR 57227A is also active in both species after oral administration. In a time-course study in mice, SR 57227A (20 mg/kg p.o.) produces a significant effect lasting 6 hours. SR 57227A (1 and 3 mg/kg i.p.) reduces the elevation of the escape failures in the learned helplessness model in rats by 50-60% on the last two days of the avoidance task, and reduces isolation-induced aggressivity in mice by 50 to 85%, an effect which is antagonised by Zacopride (1 mg/kg i.p.)[2]. | [storage]
Store at RT |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|