| Identification | Back Directory | [Name]
Carboxyatractyloside | [CAS]
77228-71-8 | [Synonyms]
Carboxyatractylosidetripotassiumsal
Carboxyatractyloside tripotassium salt
Kaur-16-ene-18,19-dioic acid, 15-hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-, (2β,15α)-
(2beta,15alpha)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioic acid | [Molecular Formula]
C31H46O18S2 | [MDL Number]
MFCD00152201 | [MOL File]
77228-71-8.mol | [Molecular Weight]
770.81 |
| Chemical Properties | Back Directory | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
H2O: ≥10mg/mL | [form ]
solid | [pka]
-3?+-.0.18(Predicted) | [color ]
white | [biological source]
Xanthium sibiricum | [Optical Rotation]
[α]/D -34 to -48°, c =0.5 in water | [Water Solubility ]
H2O: ≥10mg/mL |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
23/24/25 | [Safety Statements ]
36/37-45 | [RIDADR ]
UN 2811 6.1 / PGI | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Atractylodes lancea. | [Uses]
Carboxyatractyloside potassium salt has been used as an activator of Ca2+-induced mPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) opening. It has also been used as a adenine nucleotide translocator (ANT) inhibitor to study the inhibition of oxidative phosphorylation in intact T98G glioma cells. | [Biochem/physiol Actions]
Carboxyatractyloside is a highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carrier; i.e. adenine nucleotide translocase (ANT); causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and apoptosis. | [target]
Calcium Channel | P450 (e.g. CYP17) |
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