| Identification | Back Directory | [Name]
Poricoic acid A(F) | [CAS]
137551-38-3 | [Synonyms]
Poricoic acid A
Poricoic acid B
poricoic acid F
Poricoic acid A(F)
(2R,3R,3aR,6S,7S,9bR)-3-[(1R)-1-Carboxy-5-methyl-4-methylenehexyl]-2,3,3a,4,6,7,8,9b-octahydro-2-hydroxy-3a,6,9b-trimethyl-7-(1-methylethenyl)-1H-benz[e]indene-6-propanoic acid
1H-Benz[e]indene-6-propanoic acid, 3-[(1R)-1-carboxy-5-methyl-4-methylenehexyl]-2,3,3a,4,6,7,8,9b-octahydro-2-hydroxy-3a,6,9b-trimethyl-7-(1-methylethenyl)-, (2R,3R,3aR,6S,7S,9bR)- | [Molecular Formula]
C31H46O5 | [MDL Number]
MFCD29049473 | [MOL File]
137551-38-3.mol | [Molecular Weight]
498.69 |
| Chemical Properties | Back Directory | [Boiling point ]
664.0±55.0 °C(Predicted) | [density ]
1.11±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.63±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Poricoic acid A, isolated from Poria cocos, possesses anti-tumor activity[1]. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis[2]. | [Definition]
ChEBI:Poricoic acid A is a tricyclic triterpenoid isolated from Poria cocos. It has a role as a fungal metabolite. It is a tricyclic triterpenoid, a dicarboxylic acid and a secondary alcohol. | [target]
Immunology & Inflammation related | [References]
[1] Dong H, et al. Enrichment and separation of antitumor triterpene acids from the epidermis of Poria cocos by pH-zone-refining counter-current chromatography and conventional high-speed counter-current chromatography. J Sep Sci. 2015 Jun;38(11):1977-82. DOI:10.1002/jssc.201500077
[2] Chen DQ, et al. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Free Radic Biol Med. 2019 Apr;134:484-497. DOI:10.1016/j.freeradbiomed.2019.01.046 |
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