| Identification | Back Directory | [Name]
5,7-Dihydroxy-2-(4-hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl)-2,3-dihy dro-4H-chromen-4-one | [CAS]
77263-11-7 | [Synonyms]
abyssinone V
5,7-Dihydroxy-2-(4-hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl)-2,3-dihy dro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-[4-hydroxy-3,5-bis(3-methyl-2-buten-1-yl)phenyl]-, (2S)- | [Molecular Formula]
C25H28O5 | [MOL File]
77263-11-7.mol | [Molecular Weight]
408.49 |
| Hazard Information | Back Directory | [Uses]
Abyssinone V is a prenylated flavonoid with predicted anti-viral activity. Abyssinone V can be isolated from the stem bark of Erythrina melanacantha. Abyssinone V possesses good pharmacodynamics properties. Abyssinone V is predicted to be antivirals including anti-herpes (HSV) agent, with mechanisms comprising inhibition of polymerase, ATPase and membrane integrity[1][2]. | [Definition]
ChEBI: A trihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7 and 4' and prenyl groups at positions 3' and 5' respectively. | [References]
[1] Koch K, et al. Abyssinone V, a prenylated flavonoid isolated from the stem bark of Erythrina melanacantha increases oxidative stress and decreases stress resistance in Caenorhabditis elegans. J Pharm Pharmacol. 2019 Jun;71(6):1007-1016. DOI:10.1111/jphp.13074
[2] Kwofie SK, et al. Identification of novel potential inhibitors of varicella-zoster virus thymidine kinase from ethnopharmacologic relevant plants through an in-silico approach. J Biomol Struct Dyn. 2022;40(23):12932-12947. DOI:10.1080/07391102.2021.1977700 |
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