| Identification | Back Directory | [Name]
[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone | [CAS]
7733-96-2 | [Synonyms]
HC-056456
3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide
HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide)
HC-056456 (Synonyms: 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide)
[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone | [Molecular Formula]
C12H6N2O4S2 | [MOL File]
7733-96-2.mol | [Molecular Weight]
306.32 |
| Chemical Properties | Back Directory | [Melting point ]
113-114 °C(Solv: heptane (142-82-5)) | [Boiling point ]
572.1±60.0 °C(Predicted) | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:150.0(Max Conc. mg/mL);489.7(Max Conc. mM) | [form ]
Solid | [pka]
-4.77±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 μM). | [storage]
Store at -20°C | [References]
[1] Carlson AE, et al. Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One. 2009 Aug 31;4(8):e6844. DOI:10.1371/journal.pone.0006844 |
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