7733-96-2

中文名称 [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone

英文名称 [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone

CAS 7733-96-2

分子式 C12H6N2O4S2

分子量 306.32

MOL 文件 7733-96-2.mol

更新日期 2025/08/24 20:00:07

7733-96-2 结构式

基本信息物理化学性质安全数据图谱信息 [5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone价格(试剂级) 常见问题列表

基本信息

中文别名

化合物HC-056456

英文别名

HC-056456
3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide
HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide)
HC-056456 (Synonyms: 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide)
[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone

物理化学性质

熔点113-114 °C(Solv: heptane (142-82-5))

沸点572.1±60.0 °C(Predicted)

密度1.67±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO:150.0(Max Conc. mg/mL);489.7(Max Conc. mM)

酸度系数(pKa)-4.77±0.10(Predicted)

形态Solid

颜色White to off-white

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H319-H302-H335-H315

防范说明P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

海关编码2934999090

图谱信息

[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone(7733-96-2)核磁图(¹HNMR)

[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-112729	[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone HC-056456	7733-96-2	5mg	900元
2025/05/22	HY-112729	[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone HC-056456	7733-96-2	10mM * 1mLin DMSO	990元
2025/05/22	HY-112729	[5-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-5-ium-3-yl]-thiophen-2-ylmethanone HC-056456	7733-96-2	10mg	1400元

常见问题列表

生物活性

HC-056456 是一种有效但不完全选择性的 CatSper 通道阻断剂。HC-056456 减慢 [Na+]i 上升，IC50 为 3 µM。

靶点

CatSper

体外研究

HC-056456 similarly slows the rise of [Ca ²⁺ ] _i that is evoked by alkaline depolarization and reported by fura-2. HC-056456 also selectively and reversibly decreased CatSper currents recorded from patch-clamped sperm. HC-056456 produces a pharmacological phenocopy of the CatSper-null sperm. Acute application of HC-056456 causes rapid loss of flagellar waveform asymmetry from hyperactivated sperm, indicating that continued entry of Ca ²⁺ through CatSper channels is required to maintain hyperactivation. HC-056456 selectively and reversibly blocks CatSper currents. The specificity and reversibility of the blockade of CatSper-dependent currents by HC-056456 is examined by using patch clamp recordings. The observed current is blocked slightly more than 50% by 20 µM HC-056456 (estimated IC ₅₀ near 15 µM). In concept, it remains possible that CatSper channel heterogeneity explains residual HC-056456-resistant current. The action of HC-056456 on KSper channels, the other major cation channel observed in patch-clamped sperm, is also examined. Subsequent application of 50 µM HC-056456 results in partial blockade of this current. For HC-056456 action on KSper an IC ₅₀ near 40 µM is estimated.