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775351-65-0

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775351-65-0 Structure

775351-65-0 Structure
IdentificationBack Directory
[Name]

1,3,5-Triazine-2,4-diamine,1,6-dihydro-N,N,6-trimethyl-,(+)-(9CI)
[CAS]

775351-65-0
[Synonyms]

IMegliMin
EMD 387008
R-IMegliMin
Emd 387008 hcl
EMD 387008/R-Imeglimin
EMD 387008 (R-IMEGLIMIN) HCL
(2S)-N6,N6,2-trimethyl-1,2-dihydro-1,3,5-triazine-4,6-diamine
1,3,5-Triazine-2,4-diamine,1,6-dihydro-N,N,6-trimethyl-,(+)-(9CI)
1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, (6R)-
[Molecular Formula]

C6H13N5
[MDL Number]

MFCD19443705
[MOL File]

775351-65-0.mol
[Molecular Weight]

155.2
Chemical PropertiesBack Directory
[Boiling point ]

239.9±23.0 °C(Predicted)
[density ]

1.29±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

11.65±0.40(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P280-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1].
[in vivo]

Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, restores normal glucose tolerance, and improves insulin sensitivity[1].

Animal Model:Male C57BL/6JOlaHsd mice (4 weeks old)[1]
Dosage:200 mg/kg
Administration:Oral gavage; b.i.d.; 6 weeks
Result:A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
[References]

[1] Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64. DOI:10.2337/db14-1220
[2] Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072. DOI:10.1038/cddiscovery.2015.72
Spectrum DetailBack Directory
[Spectrum Detail]

Imeglimin(775351-65-0)1HNMR
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