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775351-91-2

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775351-91-2 Structure

775351-91-2 Structure
IdentificationBack Directory
[Name]

Corylifol C
[CAS]

775351-91-2
[Synonyms]

Corylifol C
2-(3,4-Dihydroxyphenyl)-7-hydroxy-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-hydroxy-8-(3-methyl-2-buten-1-yl)-
[Molecular Formula]

C20H18O5
[MOL File]

775351-91-2.mol
[Molecular Weight]

338.35
Chemical PropertiesBack Directory
[Boiling point ]

601.5±55.0 °C(Predicted)
[density ]

1.351±0.06 g/cm3(Predicted)
[pka]

7.56±0.40(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Corylifol C is a potent protein kinase inhibitor with IC50 valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively[1].
[References]

[1] Limper C, et al. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol. 2013 Sep;65(9):1393-408. DOI:10.1111/jphp.12107
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