| Identification | Back Directory | [Name]
6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl- | [CAS]
77879-89-1 | [Synonyms]
gilvocarcin M
AnandiMycin B, ToroMycin B, 1072A
4-(6-Deoxy-α-L-galactofuranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one
6H-Benzo[d]naphtho[1,2-b]pyran-6-one, 4-(6-deoxy-α-D-galactofuranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-
6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-alpha-galactofuranosy l)-1-hydroxy-10,12-dimethoxy-8-methyl- | [Molecular Formula]
C26H26O9 | [MOL File]
77879-89-1.mol | [Molecular Weight]
482.48 |
| Hazard Information | Back Directory | [Description]
Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus. It is active against S. aureus when used at a concentration of 32 μg/ml. Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 μg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg. Gilvocarcin M intercalates into bacteriophage PM2 DNA. It is toxic to rats with an intravenous LD50 value of 450 mg/kg. | [Uses]
Gilvocarcin M is the minor analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp.. Gilvocarcin M contains a methyl group in the 8-position, and is less active than the vinyl analogue (gilvocarcin V), which is thought to act as an inhibitor of human topoisomerase II. Gilvocarcin M displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research suggests that the gilvocarcins act as photoactivated cross-linkers of DNA to histones. | [Uses]
Gilvocarcin M is the minor analogue of a complex of C-glycoside antitumour actives isolated from a Streptomyces sp.. Gilvocarcin M contains a methyl group in the 8-position, and is less active than the vinyl analogue (gilvocarcin V), which is thought to act as an inhibitor of human topoisomerase II. Gilvocarcin M displays potent antibacterial, antifungal, antiviral and antitumour activity. Recent research suggests that the gilvocarcins act as photoactivated crosslinkers of DNA to histones. | [Uses]
Gilvocarcin M is the minor analogue of Gilvocarcin V with anti-bact, -fungal, -viral and -tumor activity. | [storage]
Store at -20°C | [References]
[1] H NAKANO. Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities.[J]. Journal of Antibiotics, 1981, 34 3: 266-270. DOI: 10.7164/antibiotics.34.266
[2] D M BALITZ. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E.[J]. Journal of Antibiotics, 1981, 34 12: 1544-1555. DOI: 10.7164/antibiotics.34.1544
[3] M MORIMOTO. Gilvocarcins, new antitumor antibiotics. 3. Antitumor activity.[J]. Journal of Antibiotics, 1981, 34 6: 701-707. DOI: 10.7164/antibiotics.34.701
[4] F TOMITA T T K Takahashi. Gilvocarcins, new antitumor antibiotics. 4. Mode of action.[J]. Journal of Antibiotics, 1982, 35 8: 1038-1041. DOI: 10.7164/antibiotics.35.1038 |
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| Company Name: |
Lynnchem
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86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
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