| Identification | More | [Name]
1,4-Dihydroxynaphthalene | [CAS]
571-60-8 | [Synonyms]
1,4-DIHYDROXYNAPHTHALENE
1,4-NAPHTHALENEDIOL
1,4-NAPHTHOHYDROQUINONE
1,4-NAPTHALENEDIOL
1,4-NDO
ALPHA-NAPHTHOHYDROQUINONE
NAPHTHALENE-1,4-DIOL
P-NAPHTHOHYDROQUINONE
1,4-dihydroxynaphthalene,1:1mixturewith1,4-naphthoquinone
1,4-naphthoquinol
1,4-Naphththalenediol
alpha-naphthoquinhydrone
Hydronaphthoquinone
Naphthalenediol-(1,4)
Naphthohydroquinone
1,4-Dihydroxynaphthalene, 95+%
1,4-DIHYDROXYNAPTHALENE
1,4-Naphthalenediol, p-Naphthohydroquinone (α) | [EINECS(EC#)]
209-336-4 | [Molecular Formula]
C10H8O2 | [MDL Number]
MFCD00003977 | [Molecular Weight]
160.17 | [MOL File]
571-60-8.mol |
| Chemical Properties | Back Directory | [Appearance]
brown to greyish powder | [Melting point ]
191-192 °C (dec.) | [Boiling point ]
246.06°C (rough estimate) | [density ]
1.0924 (rough estimate) | [refractive index ]
1.5178 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
pK1:9.37;pK2:10.93 (26°C，μ=0.65) | [color ]
Grey | [Water Solubility ]
slightly soluble | [BRN ]
1307689 | [InChI]
1S/C10H8O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,11-12H | [InChIKey]
PCILLCXFKWDRMK-UHFFFAOYSA-N | [SMILES]
Oc1ccc(O)c2ccccc12 | [CAS DataBase Reference]
571-60-8(CAS DataBase Reference) | [NIST Chemistry Reference]
1,4-Naphthalenediol(571-60-8) | [EPA Substance Registry System]
571-60-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R43:May cause sensitization by skin contact.
R36/37/38:Irritating to eyes, respiratory system and skin .
R25:Toxic if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S24:Avoid contact with skin . | [WGK Germany ]
3
| [RTECS ]
QJ4730000
| [F ]
8-10-16-23 | [TSCA ]
TSCA listed | [HS Code ]
2921450090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
brown to greyish powder | [Uses]
1,4-Dihydroxynaphthalene is frequently used in organic synthesis as a reagent. In particular, it is used in the synthesis of a pH independent and cell permeant fluorescent dye, a hydroxyl regioisomeric 3'',4''-benzorhodol, which can be used as a fluorescent chemosensor and biomarker for biological applications. | [Definition]
ChEBI: Naphthalene-1,4-diol is a naphthalenediol and a naphthohydroquinone. | [Biological Activity]
1,4-Dihydroxynaphthalene is a potent HSV-1 protease inhibitor with inhibitory effects on the HCMV protease, which can be used to study herpesviruses. | [References]
[1] LAURIE S. TSURUDA A. D J Michael W Lamé. Formation of epoxide and quinone protein adducts in B6C3F1 mice treated with naphthalene, sulfate conjugate of 1,4-dihydroxynaphthalene and 1,4-naphthoquinone[J]. Archives of Toxicology, 1995, 69 6: 362-367. DOI:10.1007/s002040050185. |
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