| Identification | More | [Name]
Sulfamide | [CAS]
7803-58-9 | [Synonyms]
DIAMINO SULFONIC ACID
LABOTEST-BB LT00077259
RARECHEM AM UF NL01
SULFAMIDE
SULFURIC DIAMIDE
SULPHAMIDE
sulphuric diamide
Suleamide
Sulfuryl amide
Sulfamide, 98+%
SULFAMIDE(4-HYDROXY-2-METHYL-2H-1,2-BENZOISOTHIAZOL-2-ACETICETHER-1,1-DIOXIDE)
Sulfuryl amine
SULFAMIDE ( SULFURYL AMIDE )
Imidosulfamic Acid
NSC 252
Sulfonyl Diamide
Sulfuryl Diamide
Sulfamamide | [EINECS(EC#)]
232-262-9 | [Molecular Formula]
H4N2O2S | [MDL Number]
MFCD00011606 | [Molecular Weight]
96.11 | [MOL File]
7803-58-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
90-92 °C(lit.)
| [density ]
1.611 g/mL at 25 °C(lit.)
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
water: soluble50mg/mL, clear, colorless to faintly yellow | [form ]
Crystalline Powder, Free From Visible Impurities | [pka]
10.87±0.60(Predicted) | [color ]
White to practically white , free from visible impurities | [PH]
5.67 at 21.7℃ and 10g/L | [Water Solubility ]
soluble | [Sensitive ]
Moisture Sensitive | [Usage]
A carbonic anhydrase inhibitor; used for treatment of cancer. | [Merck ]
14,8922 | [InChI]
1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4) | [InChIKey]
NVBFHJWHLNUMCV-UHFFFAOYSA-N | [SMILES]
NS(N)(=O)=O | [Uses]
Sulfamide and its derivatives can also be used to prepare fused thiadiazine systems, Reaction with 2-aminoacetophenones affords IH-2,1,3-benzothia- diazine 2,2-dioxides 77 (65JOC3960). The corresponding 3,4-dihydro deriv- atives are readily available from 2-aminobenzylamines with either sulfuryl chloride (70M1443) or sulfamide (66USP3278532; 71MI055). These kinds of compounds can also be obtained from N-aryl-N'-alkylsulfamides and s-trioxane in a reaction involving cyclization by intramolecular sulfamido- methylation (79JOC2032) (Scheme 30). | [CAS DataBase Reference]
7803-58-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Sulfamide(7803-58-9) | [EPA Substance Registry System]
7803-58-9(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [F ]
9 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
IRRITANT | [HS Code ]
28530090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Questions And Answer | Back Directory | [Description]
Sulfamide is a white solid substance that is normally produced by reacting sulfuryl chloride with ammonia. Sulfamide is stable under normal conditions and soluble in acetone and DMSO. Sulfamide may also refer to the functional group in organic chemistry, and it consists of at least one group attached to a nitrogen atom of sulfamide.
It is a carbonic anhydrase inhibitor and is widely used as a pharmaceutical intermediate.
Sulfamide is sensitive to moisture, thus should be kept away from water and humidity. It should also be stored away from oxidizing agents. Sulfamide should be kept in a tightly closed container and placed in a cool, dry, and well-ventilated condition.
|
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Definition]
ChEBI: The simplest of the sulfamic acids consisting of a single sulfur atom covalently bound by single bonds to two amino groups and by double bonds to two oxygen atoms. | [storage]
Store at -20°C | [Purification Methods]
Crystallise sulfamide from absolute EtOH. It decomposes at 250o. [Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I pp 482-483 1963.] |
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