| Identification | Back Directory | [Name]
N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide | [CAS]
780822-35-7 | [Synonyms]
N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide
1H-Benzimidazole-5-sulfonamide, 2,3-dihydro-N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylthio)-1-naphthalenyl]-2-oxo- | [Molecular Formula]
C19H14N6O4S2 | [MOL File]
780822-35-7.mol | [Molecular Weight]
454.48 |
| Hazard Information | Back Directory | [Uses]
hsa62 is a dual inhibitor for SIRT1 and SIRT2, with IC50 of 1.3 and 5.5 μM, respectively[1]. | [IC 50]
SIRT1: 1.3 μM (IC50); SIRT2: 5.5 μM (IC50); SIRT3: 43.6 μM (IC50) | [References]
[1] Cai H, et al., Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790. DOI:10.1021/acs.jcim.3c00556 |
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| Company Name: |
OTAVA chemicals
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| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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