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781652-57-1

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781652-57-1 Structure

781652-57-1 Structure
IdentificationBack Directory
[Name]

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
[CAS]

781652-57-1
[Synonyms]

CDPPB
mGluR5 Ligand, CDPPB
3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem
Benzamide, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)-
[Molecular Formula]

C23H16N4O
[MDL Number]

MFCD12828752
[MOL File]

781652-57-1.mol
[Molecular Weight]

364.4
Chemical PropertiesBack Directory
[Melting point ]

210-212°C
[storage temp. ]

2-8°C
[solubility ]

DMSO: ≥5mg/mL at warmed to 60°C
[form ]

powder
[color ]

white to beige
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
[Hazard Codes ]

Xn
[Risk Statements ]

22
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide  is a glutamate metabotropic (mGluR5) positive allosteric modulator, used in the treatment of Phelan-McDermid syndrome caused by 22qI3 deletion. Studies have shown that 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide suppresses the incre ase of LDH release and caspase-3 activation induced by traumatic neuronal injury.
[Biochem/physiol Actions]

CDPPB is a glutamate metabotropic mGluR5 positive allosteric modulator.
[storage]

Store at -20°C
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