| Chemical Properties | Back Directory | [solubility ]
DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM) | [form ]
Liquid | [pka]
10.02±0.20(Predicted) | [color ]
Colorless to off-white | [LogP]
3.720 (est) |
| Hazard Information | Back Directory | [Uses]
Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities[1]. | [in vivo]
Yakuchinone A (50 mg/kg, i.p., daily, 14 days) can reduce the symptoms of EAE in mice in autoimmune encephalomyelitis (EAE) mouse model[1].
| Animal Model: | Female C57BL/6 mice[1] | | Dosage: | 50 mg/kg | | Administration: | i.p., daily, 14 days | | Result: | Showed a significant EAE score reduction from Day 9 to Day 15 after EAE onset. |
| [References]
[1] Chen Huo, et al. Microbial Transformation of Yakuchinone A and Cytotoxicity Evaluation of Its Metabolites.?Int J Mol Sci. 2022 Apr 3;23(7):3992.
[2] Kuo-Kuei Huang, et al. Alpinia oxyphylla?Fruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells. Evid Based Complement Alternat Med. 2019 Mar 14;2019:6797030. DOI:10.1155/2019/6797030 |
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