| Identification | Back Directory | [Name]
N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA | [CAS]
792173-99-0 | [Synonyms]
CS-1891
SB334867/SB-334867
SB334867A free base
SB-334867 (free base)
SB-334867,CID 6604926
SB-334867 >=98% (HPLC)
N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl
N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-
1-(2-Methylbenzo[d]oxazol-5-yl)-3-(1,5-naphthyridin-4-yl)urea
1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea
1-(2-METHYL-1,3-BENZOXAZOL-6-YL)-3-(1,5-NAPHTHYRIDIN-4-YL)UREA
N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA USP/EP/BP
N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-ylurea SB334867 | [Molecular Formula]
C17H13N5O2 | [MDL Number]
MFCD06411602 | [MOL File]
792173-99-0.mol | [Molecular Weight]
319.317 |
| Chemical Properties | Back Directory | [Boiling point ]
450.5±30.0 °C(Predicted) | [density ]
1.472 | [storage temp. ]
room temp | [solubility ]
insoluble in H2O; insoluble in EtOH; ≥14.55 mg/mL in DMSO | [form ]
powder | [pka]
10.21±0.43(Predicted) | [color ]
white to beige | [CAS DataBase Reference]
792173-99-0 |
| Hazard Information | Back Directory | [Uses]
SB 334867 is an orexin 1 receptor antagonist. | [Definition]
ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative. | [Biological Activity]
sb-334867 free base is a selective antagonist of orexin-1 receptor [1].orexin-a and orexin-b are two peptides isolated from rat hypothalamus. they are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.sb-334867 free base could inhibit the orexin-a and orexin-b induced calcium responses in cho-ox1 cells with pkb values of 7.27 and 7.23, respectively. sb-334867 was more selective for ox1 receptor over ox2 receptor. it caused 32.7% and 22% inhibition of orexin-a and orexin-b induced calcium responses in cho-ox2 cells, respectively. moreover, sb-334867 was found to reduce both orexin-a-induced and fasting-induced food intake. the acute anorectic effect of it was associated with significant reductions in all active behaviours [1, 2]. | [Biochem/physiol Actions]
Lateral hypothalamic orexin neuron activation leads to the development of morphine conditioned place preference, which is preferably blocked by SB-334867. | [storage]
Store at -20°C | [References]
[1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452. |
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