| Identification | Back Directory | [Name]
ML-184 | [CAS]
794572-10-4 | [Synonyms]
ML-184
3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidin-1-ylbenzenesulfonamide
3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide
3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-(pyrrolidin-1-yl)benzene-1-sulfonamide
Benzenesulfonamide, 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)- | [Molecular Formula]
C25H34N4O3S | [MDL Number]
MFCD06367291 | [MOL File]
794572-10-4.mol | [Molecular Weight]
470.63 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white | [InChI]
InChI=1S/C25H34N4O3S/c1-19-8-7-9-23(20(19)2)28-14-16-29(17-15-28)25(30)22-18-21(33(31,32)26(3)4)10-11-24(22)27-12-5-6-13-27/h7-11,18H,5-6,12-17H2,1-4H3 | [InChIKey]
VRSJAHQGJHDACS-UHFFFAOYSA-N | [SMILES]
C1(S(N(C)C)(=O)=O)=CC=C(N2CCCC2)C(C(N2CCN(C3=CC=CC(C)=C3C)CC2)=O)=C1 |
| Hazard Information | Back Directory | [Description]
CID2440433, also known as ML-184, is a potent synthetic agonist of GPR55 (EC50 = 0.26 μM). GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 μM lysophosphatidylinositol (LPI). | [Uses]
ML-184 (CID2440433) is a selective GPR55 agonist with an EC50 of 250 nM and exhibits >100-fold selectivity for GPR55 over GPR35, CB1?and CB2. ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55[1]. ML-184(CID2440433) increases proliferation of neural stem cells and promotes neuronal differentiation?in vitro[2]. | [Definition]
ChEBI: 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]-oxomethyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide is a member of piperazines. | [storage]
Store at +4°C | [References]
[1] Kotsikorou E, et al. Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47. DOI:10.1021/bi200010k
[2] Hill JD, et al. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol. 2018 Aug;175(16):3407-3421. DOI:10.1111/bph.14387 |
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cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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