| Identification | More | [Name]
ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLATE | [CAS]
79660-46-1 | [Synonyms]
dm-7
SBB012483
BRN 4814660
6,7,8-trifL
inecarboxyL
ZINC00403393
521647_ALDRICH
CycliccompoundofLomefloxacin
uoro-1,4-dihydro-4-oxo-3-quinoL
3-ethoxycarbonyl-6,7,8-trifluoro-4-quinolinolate
ethyl 6,7,8-trifluoro-4-oxo-1H-quinoline-3-carboxylate
ETHYL 6,7,8-TRIFLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLATE
3-ethoxycarbonyl-6,7,8-trifluoro-1,4-hydro-4-oxoquinoline
ETHYL-6,7,8-TRIFLUORO-4-OXOHYDROXYQUINOLINE-3-CARBOXYLATE
Ethyl 6,7,8-trifluoro-4-oxohydroquinoline-3-carboxylate,97%
ethyl1,4-dihydro-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylate
6,7,8-TRIFLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLICACIDETHYLESTER
Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate
ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINILINECARBOXYLATE
ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLATE
6,7,8-trifluoro-4-oxo-1H-quinoline-3-carboxylic acid ethyl ester
6,7,8-trifluoro-4-keto-1H-quinoline-3-carboxylic acid ethyl ester
Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate 98%
1,4-dihydro-4-oxo-6,7,8-trifluoro-3-quinolinecarboxylicaciethylester
6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester
3-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-6,7,8-trifluoro-, ethyl ester
3-Quinolinecarboxylic acid, 6,7,8-trifluoro-1,4-dihydro-4-oxo-, ethyl ester
ETHYL 6,7,8-TRIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLATE ISO 9001：2015 REACH | [Molecular Formula]
C12H8F3NO3 | [MDL Number]
MFCD00276021 | [Molecular Weight]
271.19 | [MOL File]
79660-46-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
2
| [RTECS ]
VB2009830
| [HazardClass ]
IRRITANT | [HS Code ]
29334910 |
| Hazard Information | Back Directory | [Chemical Properties]
beige to beige-brown powder | [General Description]
Ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate is also referred to as 3-ethoxycarbonyl-6,7,8-trifluoro-1,4-hydro-4-oxoquinoline. | [Synthesis]
General procedure for the synthesis of ethyl 6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate from diethyl 2-[[(2,3,4-trifluorophenyl)amino]methylene]malonate: Compound 2 (5.30 g, 16.70 mmol) was dissolved in diphenyl ether (35 mL), and the reaction was carried out at reflux for 8 hr at 250 °C. After completion of the reaction, the reaction mixture was cooled and the precipitate precipitated was collected by filtration. The precipitate was washed with hexane and subsequently recrystallized with ethanol to give the target product 3 as a white solid. | [References]
[1] Synthetic Communications, 2009, vol. 39, # 24, p. 4375 - 4383
[2] Tetrahedron, 2007, vol. 63, # 9, p. 2093 - 2097
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 4, p. 1232 - 1244
[4] Tetrahedron, 1992, vol. 48, # 29, p. 6135 - 6150
[5] Magnetic Resonance in Chemistry, 1996, vol. 34, # 11, p. 972 - 978 |
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