| Identification | Back Directory | [Name]
NERIDRONATE SODIUM HYDRATE | [CAS]
79778-41-9 | [Synonyms]
NERIXIA
Neridronic
NERIDRONATE
NERIDRONIC ACID
NERIDRONATE SODIUM HYDRATE
Neridronate >=97% (NMR), solid
Neridronate
DISCONTINUED, offer N390025
6-amino-1-hydroxyhexane-1,1-diphosphonate
6-amino-1-hydroxyhexane-1,1-diphosphonic acid
6-AMINO-1-HYDROXYHEXYLIDENE BISPHOSPHONIC ACID
(6-AMino-1-hydroxyhexane-1,1-diyl)diphosphonic acid
Phosphonic acid,P,P'-(6-aMino-1-hydroxyhexylidene)bis-
6-Amino-1-hydroxyhexylidene bisphosphonic acid, Neridronic acid, Nerixia | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C6H17NO7P2 | [MDL Number]
MFCD08060095 | [MOL File]
79778-41-9.mol | [Molecular Weight]
277.15 |
| Chemical Properties | Back Directory | [Melting point ]
245° | [Boiling point ]
600.1±65.0 °C(Predicted) | [density ]
1.658±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: 8 mg/mL, soluble
| [form ]
solid
| [pka]
1.93±0.10(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Description]
Neridronic acid was launched in Italy as intravenous or intramuscular injection for the
treatment of osteogenesis imperfecta. It is the first drug launched worldwide for this
“orphan disease” characterized by a fragility of the bone. Sufferers risk frequent fractures
commencing during infancy, eventually leading to bone deformation and a severe
deterioration of the quality of life and life expectancy. Neridronic acid is structurally related
to the second generation of bisphosphonates characterized by an amino terminal group
and can be synthesized by treating E-aminocaproic acid with phosphoric acid and
phosphorous trichloride. Bisphosphonates, synthetic analogs of the endogenous mineral
deposition inhibitor pyrophosphate, are extremely potent inhibitors of bone resorption and
increase bone mineral density, possibly by inhibiting the activity of osteoclasts and
promoting the death of these bone-eroding cells. In vitro, neridronic acid was a poor
inhibitor of phagocytosis, but significantly and dose dependently inhibited 8glucuronidase
release and superoxide anion production in the rat peritoneal macrophage, two parameters
that may have a part in bone resorption. In a clinical study on patients with osteogenesis
imperfecta, neridronic acid increased remarkably bone mass in young growing individuals.
In adults the changes were less important but still significant. | [Originator]
lnstituto Gentili (Italy) | [Definition]
ChEBI:Neridronic acid is a 1,1-bis(phosphonic acid). | [Brand name]
Nerixia | [Biochem/physiol Actions]
Neridronate is a bone resorption inhibitor. It is used to treat Osteogenesis Imperfecta, an "orphan disease" characterized by a fragility of the bone enough to be named the "illness of bones of crystal". | [Synthesis]
6-
Aminohexanoic acid (152) was reacted with phosphorus
trichloride and phosphorous acid at 85??C, and then water was added to generate free diphosphonic acid 16 in 78%
overall yield [59].
| [storage]
Store at -20°C |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|